1.Aeschlimann FA, Batu ED, Canna SW, Go E, Gul A, Hoffmann P, et al. A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease. Ann Rheum Dis. 2018;77(5):728-35. 2.Duncan CJA, Dinnigan E, Theob...
However, in the ITP-MSCs, IkB knockdown rescued the inhibition of megakaryocytopoiesis and thrombopoiesis by decreasing the expression of NF-kB. Because the native expression of A20 was lower in ITP-MSCs, exogenous expression from A20-cDNA was amplified, which facilitated the differentiation of ...
1.Aeschlimann FA, Batu ED, Canna SW, Go E, Gul A, Hoffmann P, et al. A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease. Ann Rheum Dis. 2018;77(5):728-35. 2.Duncan CJA, Dinnigan E, Theob...
TNFAIP3, also named A20, is a cytoplasmic zinc finger protein that inhibits nuclear factor kappa-B (NFKB) activity and tumor necrosis factor (TNF)-mediated programmed cell death. A20 is a ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities, and involved in ...
TNFAIP3, also named A20, is a cytoplasmic zinc finger protein that inhibits nuclear factor kappa-B (NFKB) activity and tumor necrosis factor (TNF)-mediated programmed cell death. A20 is a ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities, and involved in ...
1.1TNFAIP3负向调节NF-kB信号通路最初研究发现TNFAIP3是内皮细胞受到TNF-a刺激后快速诱导表达的基因。随后研究提示TNFAIP3基因敲除小鼠模型自发表现为多器官炎症、恶病质以及围生期 死亡,证实TNFAIP3基因在维持机体的免疫稳态中发挥着关键调控作用,具有强大的抗炎能力[3]。目前研究表明TNFAIP3的功能主要归因于其编码的...
The zinc finger protein A20, also called tumor necrosis factor, alpha-induced protein 3 (TNFAIP3), is a TNF- and IL-1-inducible protein that negatively regulates NF-kB-dependent gene expression. A20 is encoded by an immediate early response gene whose expression is induced by different inflamma...
aTNFAIP3encodes the A20 protein, which forms part of a negative feedback loop to dampen NF-kB-mediated immune activation.bHiC plots for the lymphoblastoid B cell line GM12878, with color intensity proportional to the interaction frequency between genomic coordinates (x-axis). Boxes indicate the ...
A20, encoded by TNFAIP3 on chromosome 6, is an ubiquitin-editing enzyme that plays a central role in the control of nuclear factor κB (NF-kB) activation. This enzyme is expressed in most cell types at low basal levels but is rapidly induced on tumor necrosis factor (TNF)-or Toll-like...
别 名 Listeria induced; A20-binding inhibitor of NF-kappa-B activation 3; ABIN-3; ABIN-3 beta; FLJ21162; LIND; Listeria induced gene protein; TNFAIP3 interacting protein 3; TNFAIP3-interacting protein 3 beta; TNIP3; TNIP3 beta; TNIP3_HUMAN. 浓 度 1mg/1ml 规 格 0.2ml/200μg ...