Methylprednisolone inhibition of TNF-alpha expression and NF-kB activation after spinal cord injury in rats[J].Brain Research Molecular Brain Research,1998,(02):135-142.doi:10.1016/S0169-328X(98)00142-9.Xu,J.,Fan,G.,Chen,S.,Wu,Y.,Xu,X. M.,Hsu,C. Y.Methylprednisolone inhibition of ...
Low level laser therapy prevent endothelial cells from TNF-alpha/cycloheximide-induced apoptosis by modulating P38 MAPK/NF-kB pathway - Physiotherapydoi:10.1016/j.physio.2015.03.411Y.-J. ChengH.-C. OuC.-H. LeeElsevier LtdPhysiotherapyCheng Y-J, Ou H-C, Lee C-H. Low level laser therapy ...
1a). Importantly, we also observed that TNF-α-induced microglia activation resulted in increased levels of ph-NF-kB p65 (p = 0.011; Fig. 1b), suggesting that the overexpression of the inflammatory mRNAs may be achieved through the activation of the NF-kB pathway....
TNF alpha 与其受体结合,主要是 TNFR1 和 TNFR2,然后传递信号以实现炎症和细胞死亡等生物学功能。TNF alpha 通过 TNFR2 受体激活 NF-κB 通路促进癌细胞生长、侵袭和转移,但抗 TNF-α 抗体能显着抑制结肠炎相关癌症 (CAC) 小鼠的肿瘤发展。TNF alpha 作为一种原神经原因子可激活 SAPK/JNK 通路,并能够促进神经...
TNF-alpha increases tracheal epithelial asbestos and fiberglass binding via a NF-kB-dependent mechanism.Discusses a study which determined the effects of tumor necrosis factor-alpha on fiber binding to tracheal epithelial cells. Materials and methods; Results; Discussion....
intracellular C-terminal domain of the glutamate transporter, rendering it inactive.[43]Stimulation of the NFkB pathway in astrocytes by TNF-α, decreases the transcription and expression of EAAT2 on the glial membrane, reducing glutamate uptake from the synaptic cleft.[44]Although this response ...
TNF-α can be activated by Pathogen-Associated Molecular Patterns (PAMPs) such as bacterial or viral DNA, flagellin, or lipopolysaccharide (LPS), through the NFkB pathway. PAMPs can be recognized by Toll-like receptors (TLRs) thereby initiating a kinase cascade which phosphorylates and degrades ...
Curcumin, a potential inhibitor of upregulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kB and JNK pathway. Biomed Environ Sci. 2009;22:32e39.Wang SL, Li Y, Wen Y, Chen YF, Na LX, Li ST, Sun CH (2009) Curcumin, a potential inhibitor of up-...
《Betatrophin对TNFalpha或IL-1beta诱导NF-kappaB活化的负调控机制研究》是依托华中科技大学，由张煜担任项目负责人的青年科学基金项目。中文摘要 非可控炎症是糖尿病、癌症等多种重大疾病的主要诱因，调控紊乱是造成炎症处于非可控状态的重要原因。NF-kB能诱导一系列炎症相关蛋白表达，在炎症反应调控中发...