这是一个复杂的问题,我只能提供你思考角度.1.是在哪类细胞上做信号通路?2.是以IL-6作为诱导产生的,...
Gambogic acid inhibits TNF-a-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-kB signaling path- ways. Acta Pharmacol. Sin. 33, 531e541.Lu L, Tang D, Wang L, Huang L, Jiang G, Xiao X, et al. Gambogic acid inhibits TNF-α-induced invasion of ...
本项目计划进一步锁定Betatrophin的分子靶标，解析其调控NF-kB激活的具体机制，探讨其是否通过调控NF-kB活性而影响胰岛素通路。该研究有望揭示一种NF-kB活性调控的新机制，从而为糖尿病等炎症相关疾病的治疗提供理论依据。结题摘要 炎症调控紊乱与败血症、糖尿病、癌症等多种疾病密切相关。转录因子NF-κB...