NFkB was accumulated in cisplatin‐resistant cell lines and in cancer stem cells (CSC), and the administration of TNF‐alpha increased the CSC, suggesting that TNF‐alpha/NFkB signaling is involved in the accumulation of CSC. TNF‐alpha stimulation also increased the histone deacetylases HDAC1 ...
► NFκB–p65 (RelA) binds to kB-sites in Cldn5 promoter and cotransfection of NFκB–p65 (RelA) expression plasmid with Cldn5 promoter–luciferase construct mimics TNFα induced Cldn5 promoter suppression. ► Suppressive effect of TNFα on Cldn5 expression is observable in primary cerebral...
TNF-alpha increases tracheal epithelial asbestos and fiberglass binding via a NF-kB-dependent mechanism.Discusses a study which determined the effects of tumor necrosis factor-alpha on fiber binding to tracheal epithelial cells. Materials and methods; Results; Discussion....
这是一个复杂的问题,我只能提供你思考角度.1.是在哪类细胞上做信号通路?2.是以IL-6作为诱导产生的,...
Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine that activates NF-kB, MAPK, and PI3K/AKT pathways. Activated T cells and macrophages are the primary producers of TNF-α in response to inflammation and infectious conditions. Many other cell types ha...
TNF-α can be activated by Pathogen-Associated Molecular Patterns (PAMPs) such as bacterial or viral DNA, flagellin, or lipopolysaccharide (LPS), through the NFkB pathway. PAMPs can be recognized by Toll-like receptors (TLRs) thereby initiating a kinase cascade which phosphorylates and degrades ...
These cytokines may induce resorption indirectly by affecting the production of the essential osteoclast differentiation factor, receptor activator of NF-kB ligand, and/or its soluble decoy receptor, osteoprotegerin, by osteoblast/stromal cells or directly by enhancing proliferation and/or activity of ...
Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene. 2014;34:3493–503.De Simone V, Franze E, Ronchetti G, Colantoni A, Fantini MC, Di Fusco D, ... V De Simone,E Franzè,G Ronchetti,... - 《Oncogene...
Curcumin, a potential inhibitor of upregulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kB and JNK pathway. Biomed Environ Sci. 2009;22:32e39.Curcumin, a Potential Inhibitor of Up-regulation of TNF-alpha and IL-6 Induced by Palmitate in 3T3-L1 ...