Interestingly, miR-342 overexpression in N9 microglia was sufficient to activate the NF-kB pathway by inhibiting BAG-1, leading to increased secretion of TNF-α and IL-1β. Conversely, miR-342 inhibition led to a strong decrease in the levels of these cytokines after TNF-α activation. In ...
1a). Importantly, we also observed that TNF-α-induced microglia activation resulted in increased levels of ph-NF-kB p65 (p = 0.011; Fig. 1b), suggesting that the overexpression of the inflammatory mRNAs may be achieved through the activation of the NF-kB pathway....
TNF-alpha increases tracheal epithelial asbestos and fiberglass binding via a NF-kB-dependent mechanism.Discusses a study which determined the effects of tumor necrosis factor-alpha on fiber binding to tracheal epithelial cells. Materials and methods; Results; Discussion....
TNF alpha 通过 TNFR2 受体激活 NF-κB 通路促进癌细胞生长、侵袭和转移,但抗 TNF-α 抗体能显着抑制结肠炎相关癌症 (CAC) 小鼠的肿瘤发展。TNF alpha 作为一种原神经原因子可激活 SAPK/JNK 通路,并能够促进神经元替代和脑修复以应对脑损伤。TNF-alpha/TNFSF2 蛋白, Human 是一种由大肠杆菌表达的重组蛋白,...
Low level laser therapy prevent endothelial cells from TNF-alpha/cycloheximide-induced apoptosis by modulating P38 MAPK/NF-kB pathway - Physiotherapydoi:10.1016/j.physio.2015.03.411Y.-J. ChengH.-C. OuC.-H. LeeElsevier LtdPhysiotherapyCheng Y-J, Ou H-C, Lee C-H. Low level laser therapy ...
这个还跟细胞特异性有关系。一般来说，TNF-a 能激活NF-kB，然后IL-6是NF-kB下游的基因，也被激活。
Curcumin, a potential inhibitor of upregulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kB and JNK pathway. Biomed Environ Sci. 2009;22:32e39.Wang SL, Li Y, Wen Y, Chen YF, Na LX, Li ST, Sun CH (2009) Curcumin, a potential inhibitor of up-...
TNF-α can be activated by Pathogen-Associated Molecular Patterns (PAMPs) such as bacterial or viral DNA, flagellin, or lipopolysaccharide (LPS), through the NFkB pathway. PAMPs can be recognized by Toll-like receptors (TLRs) thereby initiating a kinase cascade which phosphorylates and degrades ...
Activation of NF-kB and increased MnSOD expression were potentiated by thiol reducing agents. In contrast, thiol oxidizing or alkylating agents inhibited both NF-kappa B activation and elevated MnSOD expression in response to TNF alpha or IL-1. Since protease inhibitors TPCK and TLCK can inhibit...