Interestingly, miR-342 overexpression in N9 microglia was sufficient to activate the NF-kB pathway by inhibiting BAG-1, leading to increased secretion of TNF-α and IL-1β. Conversely, miR-342 inhibition led to a strong decrease in the levels of these cytokines after TNF-α activation. In ...
TNF alpha 通过 TNFR2 受体激活 NF-κB 通路促进癌细胞生长、侵袭和转移,但抗 TNF-α 抗体能显着抑制结肠炎相关癌症 (CAC) 小鼠的肿瘤发展。TNF alpha 作为一种原神经原因子可激活 SAPK/JNK 通路,并能够促进神经元替代和脑修 肿瘤坏死因子 α (TNF alpha) 是一种有效的促炎细胞因子。TNF alpha 与其受体...
TNF-alpha increases tracheal epithelial asbestos and fiberglass binding via a NF-kB-dependent mechanism.Discusses a study which determined the effects of tumor necrosis factor-alpha on fiber binding to tracheal epithelial cells. Materials and methods; Results; Discussion....
这个还跟细胞特异性有关系。一般来说，TNF-a 能激活NF-kB，然后IL-6是NF-kB下游的基因，也被激活。
TNF-α can be activated by Pathogen-Associated Molecular Patterns (PAMPs) such as bacterial or viral DNA, flagellin, or lipopolysaccharide (LPS), through the NFkB pathway. PAMPs can be recognized by Toll-like receptors (TLRs) thereby initiating a kinase cascade which phosphorylates and degrades ...
Both type I and type II receptors bind TNF-alpha with comparable affinity and can promote NFkB activation (24-27). Only TNF RI, however, contains a cytoplasmic death domain which triggers the activation of apoptosis (3, 28). Soluble forms of both types of receptors are released into human...
Low level laser therapy prevent endothelial cells from TNF-alpha/cycloheximide-induced apoptosis by modulating P38 MAPK/NF-kB pathway - Physiotherapydoi:10.1016/j.physio.2015.03.411Y.-J. ChengH.-C. OuC.-H. LeeElsevier LtdPhysiotherapyCheng Y-J, Ou H-C, Lee C-H. Low level laser therapy ...
TNF alpha 通过 TNFR2 受体激活 NF-κB 通路促进癌细胞生长、侵袭和转移,但抗 TNF-α 抗体能显着抑制结肠炎相关癌症 (CAC) 小鼠的肿瘤发展。TNF alpha 作为一种原神经原因子可激活 SAPK/JNK 通路,并能够促进神经元替代和脑修复以应对脑损伤。TNF-alpha/TNFSF2 蛋白, Human 是一种由大肠杆菌表达的重组蛋白,...
Conclusion Curcumin reverses palmitate-induced insulin resistance state in 3T3-L1 adipocytes through the NF-kB and JNK pathway.Shao-LingWANGandYingLIandYingWENandYan-FengSDOSBiomedical & Environmental SciencesWang, S.L.; Li, Y.; Wen, Y.; Chen, Y.F.; Na, L.X.; Li, S.T.; Sun, C.H...