The top upregulated pathway in SDS was TNF-alpha signaling via NF-kB. Interestingly, when we mapped this pathway back to our single cell roadmap we found that it was activated to varying degrees in cells at the HSC/MPP stage, but not in more committed progenitors. This finding is ...
(EMSA) that was performed using an NFKB UAS probe. Nuclear extracts from cells overexpressing FL TRAF2 (lanes 3 and 4) show TNF-alpha induced shifts significantly stronger in comparison to control (lanes 1 and 2). TRAF2-TR overexpression blocks formation of NF-kB and, as a result, no ...
Alpha-lipoic acid inhibits TNF-alpha induced NF-kappa B activation through blocking of MEKK1-MKK4-IKK signaling cascades The therapeutic effects of α-lipoic acid (α-LA) via NF-κB down regulation were demonstrated on joint inflammation and erosion in an animal model. In thi... CK Lee,EY...
Transmembrane TNF-α mediates "forward" and "reverse" signaling, inducing cell death or survival via the NF-κB pathway in Raji Burkitt lymphoma cells[J]. J Leukocyte Biol, 2008, 84(3): 789-797.Zhang H,Yan D,Shi X,etc.Transmembrane TNF-alpha mediates forward and reverse signaling, ...
TNF-alpha regulates microglial activation via the NF-kappa B signaling pathway in systemic lupus erythematosus with depressionSystemic lupus erythematosusMicrogliaNeuroinflammationTumor necrosis factor-alphaPDTCThis study aimed to investigate the effects of tumor necrosis factor-alpha (TNF-alpha) on systemic ...
IFN-gamma and TNF-alpha synergistically induce mesenchymal stem cell impairment and tumorigenesis via NFkappaB signaling. Stem Cells. 31, 1383-1395 (2013).Wang L, Zhao Y, Liu Y, et al. IFN ‐γand TNF ‐α Synergistically Induce Mesenchymal Stem Cell Impairment and Tumorige...
Zhang XM, Zheng XY, Sharkawi SS, et al. Possible protecting role of TNF -α in kainie acid - induced neurotoxicity via down - regulation of NF - KB sigualing pathway [J]. Curt Alzheimer Res, 2013, 10 (6) : 660 -669.Xing-Mei Zhang,Xiang-Yu Zheng,S S Sharkaw...
It was demonstrated that uric acid induced the expression of TNF-alpha via the ROS-MAPK-NF-kappa B signaling pathway in VSMCs, providing novel evidence supporting the pro-inflammatory and pro-atherosclerotic effects of uric acid.Tang, LirongXu, Yu'eWei, YingHe, Xu...
(EMSA) that was performed using an NFKB UAS probe. Nuclear extracts from cells overexpressing FL TRAF2 (lanes 3 and 4) show TNF-alpha induced shifts significantly stronger in comparison to control (lanes 1 and 2). TRAF2-TR overexpression blocks formation of NF-kB and, as a result, no ...
Zhang P, Wu C, Huang XH, Shen CL, Li L, Zhang W, Yao CZ. Aspirin suppresses TNF-alpha-induced MMP-9 expression via NF-kappaB and MAPK signaling pathways in RAW264.7 cells. Exp Ther Med 2017; 14: 5597-5604.Zhang P, Wu C, Huang XH, Shen CL, Li L, Zhang W, Yao CZ, Zhang ...