NFKB activation, TNF-α expression, and apoptosis in the AIDS-Dementia-Complex. Journal of Neurovirology, 6: 537-543, 2000.Rostasy K, Monti L, Yiannoutsos C et al. NFkB activation, TNF-alpha expression, and apoptosis in the AIDS-Dementia-Complex. J Neurovi- rol 2000; 6:537-43....
核因子-kappaB(NF-κB)被促炎刺激激活,包括细胞因子(肿瘤坏死因子alpha(TNFα)、白细胞介素-1(IL-1β))、微生物感染(细菌/脂多糖(LPS)、病毒)、受体配体(凝血酶、CD40配体(CD40L)、B细胞激活因子(BAFF))和应激(内质网(ER)应激、活性氧(ROS))。刺激释...
有两种类型的Nf-kB信号通路:典型和非典型。两者都需要通过IkB抑制剂的翻译后修饰来激活。典型途径激活主要发生在BCR、TCR、TLR4JL-IR或TNF-R受体,而非典型途径涉及CD40L、BAFF或淋巴毒素-B的受体激活。 研究热门靶点: Human NFKBIA NFKB1 RELB (Phospho-S573) Human NFkB p65 IKK alpha/beta IKBKG ...
NF-kB 的读法是按照字母的英文发音，即 N-F-卡pe-B，其中卡pe是 kappa 的读音，第一声调。TNF-alpha 是肿瘤坏死因子 alpha 的简称，是一种细胞因子，可以引起细胞的凋亡、增殖和分化3。TNF-alpha 的读法也是按照字母的英文发音，即 T-N-F-阿尔法，其中阿尔法是 alpha 的读音，第一声调。
KB(nuclearfactorofkappaB,NF—KB)在Au发病过程中的作用 的研究最为深入,现就NF—KB和TNF—在急性肺损伤中的作 用机制进行综述. 1TNF一0【在ALI中的作用 肿瘤坏死因子(tumornecrosisfactor一仪,TNF一理)主要由 单核巨噬细胞产生,但PMN(多形核白细胞),淋巴细胞,嗜酸 ...
转录因子NF-kB的激活在炎症介导的低血糖中发挥关键的作用[1]。以往也有研究显示 NF-kBp65能抑制糖皮质激素或cAMP诱导的PEPCK的转录[2]。而TNF-α通过激活核受 体辅抑制物HDAC3-SMRT募集至PEPCK基因启动子,进而抑制PEPCK基因的转录,且 TNF-α对PEPCK基因转录的抑制依赖于IKK/NF-kB通路的激活[3]。因此,我们假设...
Further, NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-binding. The NFkB complex is expressed in most cell types, and is primarily found in the cytoplasm in an inactive state in association with I-kappa-B. Phosphorylation of I-kappa-B releases ...
1a). Importantly, we also observed that TNF-α-induced microglia activation resulted in increased levels of ph-NF-kB p65 (p = 0.011; Fig. 1b), suggesting that the overexpression of the inflammatory mRNAs may be achieved through the activation of the NF-kB pathway....
Further, NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-binding. The NFkB complex is expressed in most cell types, and is primarily found in the cytoplasm in an inactive state in association with I-kappa-B. Phosphorylation of I-kappa-B releases ...
产品活性:TNF-α (31-45), human 是一种有效的 NF-kB 通路激活剂,也是一种促炎细胞因子,可诱导坏死或凋亡。TNF α 通过 TNFR2 刺激 NF-κB 通路,促进癌症生长、侵袭和转移。 生物活性:TNF-α (31-45), human 是肿瘤坏死因子-α的肽。 IC50 & Target:NF-κB ...