目的:通过观察肿瘤坏死因子(TNF-α)以及核转录因子κB(NF-κB)在颅脑损伤后脑组织中的表达变化,初步探讨两者在颅脑损伤后继发性脑损伤中的意义。方法:健康成年雄性SD大鼠64只,体重230-310g,随机分成对照组8只和颅脑损伤组56只,颅脑损伤组在外伤后1h、3h、6h、12h、24h、3d、7d处死,每组处死8只。取损伤灶周围的...
Extracellular stimuli signal for activation of the transcription factor NFkappaB, leading to gene expression regulating processes involved in immune responses, inflammation, and cell survival. Tumor necrosis factor-alpha (TNFalpha) activates NFkappaB via a well-defined kinase pathways involving NFkappaB-in...
Electroacupuncture inhibits apoptosis of splenic lymphocytes in traumatized rats through modulation of the TNF-alpha/NF-kappa B signaling pathway 喜欢 0 阅读量: 29 作者:Chi,Meng,Wang,Kun,Guonian,Zhang,Jian,Wu,Huaxing,Li 摘要: Surgical trauma leads to a severe deterioration of 关键词:...
Inhibition of NF-kappa B activity might contribute to the protective effect of heat shock response on TNF-alpha induced endothelial cell apoptosis. 来自 Wolters Kluwer 喜欢 0 阅读量: 47 作者:J You,Z Lin,W Xiao,M Lui,Z Luo DOI: 10.1097/00024382-199906001-00112 ...
Cytokine signaling involves the participation of many adaptor proteins, including the docking protein TNF receptor-associated factor-2 (TRAF-2), which is believed to transmit the TNF-alpha signal through both the I kappa B/NF-kappa B and c-Jun N-terminal kinase (JNK)/stress-related protein ki...
Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNF|[alpha]||[sol]|NF-|[kappa]|B signaling axis 来自 Semantic Scholar 喜欢 0 阅读量: 45 作者:Zak, Z,Gelebart, P,Lai, R 摘要: Leukemia is one of the leading journals in hematology and oncology. It is ...