Signaling pathway via TNF-α/NF-κB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis Nakamura T, et al .: Signaling pathway via TNF-{alpha}/NF-{kappa}B in intestinal epithelial cells may be directly involved in colitis-associated carcino......
目的:通过观察肿瘤坏死因子(TNF-α)以及核转录因子κB(NF-κB)在颅脑损伤后脑组织中的表达变化,初步探讨两者在颅脑损伤后继发性脑损伤中的意义。方法:健康成年雄性SD大鼠64只,体重230-310g,随机分成对照组8只和颅脑损伤组56只,颅脑损伤组在外伤后1h、3h、6h、12h、24h、3d、7d处死,每组处死8只。取损伤灶周围的...
The signaling transduction mechanism mediated by tumor necrosis factor-alpha (TNF-alpha) in the alveolar epithelium is not well characterized. It was subsequently hypothesized that recombinant murine TNF-alpha (rmTNF-alpha) selectively regulates the inhibitory kappa B (I kappa B-alpha)/nuclear factor...
Tumor necrosis factor (TNF ) is a potent pro-inflammatory cytokine that plays an important role in immunity and inflammation, in the control of cell proliferation, differentiation and apoptosis. This paper presents a simulation study of the TNF mediated NF- B signaling pathway based on a system-...
A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig rec... Secretory Abs constitute the first line of specific immune defense at mucosal surfaces. Such Abs are generated by the active transport ...
Vitamin C Suppresses TNFα-Induced NFκB Activation by Inhibiting IκBα Phosphorylation Carcamo JM, Pedraza A, Borquez-Ojeda O, Golde DW (2002) Vitamin C suppresses TNF alpha-induced NF kappa B activation by inhibiting I kappa B alpha phosphorylation. Biochemistry 41:12995–3002... JM Cárcam...
Telmisartan Inhibits TNF alpha-Induced Leukocyte Adhesion by Blocking ICAM-1 Expression in Astroglial Cells but Not in Endothelial Cells adhesion to astrocytes, and that this response was mediated by the inhibition of JNK/ERK1/2/NF-kappa B activation and in the PPAR-independent manner. ... C ...
Cytokine signaling involves the participation of many adaptor proteins, including the docking protein TNF receptor-associated factor-2 (TRAF-2), which is believed to transmit the TNF-alpha signal through both the I kappa B/NF-kappa B and c-Jun N-terminal kinase (JNK)/stress-related protein ki...
Since TNF-alpha activation of most of these factors is dependent on the NF-kappa B pathway, this latter was studied in TNF-alpha-activated PR. BS-EAcf inhibited the TNF-alpha-induced phosphorylation and degradation of total I kappa B alpha as well as phosphorylation of NF-kappa B p65. ...
Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNF|[alpha]||[sol]|NF-|[kappa]|B signaling axis 来自 Semantic Scholar 喜欢 0 阅读量: 43 作者:Zak, Z,Gelebart, P,Lai, R 摘要: Leukemia is one of the leading journals in hematology and oncology. It is ...