TNF-alpha regulates microglial activation via the NF-kappa B signaling pathway in systemic lupus erythematosus with depressionSystemic lupus erythematosusMicrogliaNeuroinflammationTumor necrosis factor-alphaPDTCThis study aimed to investigate the effects of tumor necrosis factor-alpha (TNF-alpha) on systemic ...
Signaling pathway via TNF-α/NF-κB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis Nakamura T, et al .: Signaling pathway via TNF-{alpha}/NF-{kappa}B in intestinal epithelial cells may be directly involved in colitis-associated carcino......
In a similar way NFkappaBi is responsible for a 30% and 70% reduction in TNFalpha gene transcription at 5 and 6 hours, respectively, following treatment with LPS (Figure 1B). Figure 1 Activation of p38 MAP Kinase and NFkappaB pathways regulate LPS induced TNFalpha synthesis from human ...
Anti-Inflammatory Effects of Boldine and Reticuline Isolated from Litsea cubeba through JAK2/STAT3 and NF-kappa B Signaling Pathways The anti-inflammatory effects of boldine and retic Yang,Xinyao,Gao,... - 《Planta Medica Natural Products & Medicinal Plant Research》 被引量: 3发表: 2018年 Bet...
This complex activates nuclear factor kappa B (NF-κB) and promotes cell survival and antiapoptotic activities. TNFR1 can be also internalized into the cytoplasm, which is dependent on the TRID domain. Subsequently, a cytosolic complex II can be formed by the recruitment of Fas-associated protein...
Blood and synovial fluid were collected after a short incubation period and TNF-alpha, NF-kappa B, and IkB-alpha levels were measured via flow cytometry. Additionally, we assessed the effects of H4R engagement on the expression of IL-1 beta, TNF-alpha, and NF-kappa B mRNAs and the ...
NF-kappa BProteinsReceptorsTumor Necrosis Factor白细胞介素1白细胞介素8肠粘膜Cytokine signaling involves the participation of many adaptor proteins, including the docking protein TNF receptor-associated factor-2 (TRAF-2), which is believed to transmit the TNF-alpha signal through both the I kappa B...
Zhang,H. et al.Transmembrane TNF-{alpha} mediates "forward" and "reverse" signaling, inducing cell death or survival via the NF-{kappa}B pathway in Raji Burkitt lymphoma cells. Journal of Leukocyte Biology . 2008H. Zhang, D. Yan, X. Shi, H. Liang, Y. Pang, N. Qin, et al., ...
It was demonstrated that uric acid induced the expression of TNF-alpha via the ROS-MAPK-NF-kappa B signaling pathway in VSMCs, providing novel evidence supporting the pro-inflammatory and pro-atherosclerotic effects of uric acid.Tang, LirongXu, Yu'eWei, YingHe, Xu...
We concluded that AMPA promotes TNF-alpha release in RAW264.7 macrophages likely through the following signaling cascade: AMPAR activation -> ROS generation -> c-Src phosphorylation -> NF-kappa B activation -> TNF-alpha. elevation. The study suggests that AMPAR may participate in macrophage ...