TNF-alpha regulates microglial activation via the NF-kappa B signaling pathway in systemic lupus erythematosus with depressionSystemic lupus erythematosusMicrogliaNeuroinflammationTumor necrosis factor-alphaPDTCThis study aimed to investigate the effects of tumor necrosis factor-alpha (TNF-alpha) on systemic ...
TNF-alpha modulates angiopoietin-1 expression in rheumatoid synovial fibroblasts via the NF-kappa B signalling pathway. Angiopoietin-1 (Ang-1) is one of a family of ligands for the Tie-2 receptor which has been demonstrated to be involved in angiogenesis. Little is known abo... BB Scott,PF...
inhibitory effect on the proliferation of fibroblast-like synoviocytes (FLS) via de-regulation of the nuclear factor-kappa B (NF-κB) signaling pathway. ... A.,Ochaion,and,... - 《Biochemical Pharmacology》 被引量: 131发表: 2008年 Inhibitory Effect of Astragalus Polysaccharides on Lipopolysacchar...
In a similar way NFkappaBi is responsible for a 30% and 70% reduction in TNFalpha gene transcription at 5 and 6 hours, respectively, following treatment with LPS (Figure 1B). Figure 1 Activation of p38 MAP Kinase and NFkappaB pathways regulate LPS induced TNFalpha synthesis from human ...
Blood and synovial fluid were collected after a short incubation period and TNF-alpha, NF-kappa B, and IkB-alpha levels were measured via flow cytometry. Additionally, we assessed the effects of H4R engagement on the expression of IL-1 beta, TNF-alpha, and NF-kappa B mRNAs and the ...
Zhang,H. et al.Transmembrane TNF-{alpha} mediates "forward" and "reverse" signaling, inducing cell death or survival via the NF-{kappa}B pathway in Raji Burkitt lymphoma cells. Journal of Leukocyte Biology . 2008Zhang, H., Yan, D., Shi, X., Liang, H., Pang, Y., Qin, N., Chen...
Finally, we showed that TNF alpha time-dependently activated NF-kappa B, AKT, ERK, p38 MAPK signaling pathways, and elevated Snail stability by activating AKT pathway that subsequently inhibited GSK-3 beta activity. Taken together, these results reveal that stabilization of Snail via AKT/GSK-3 ...
Luteolin Prevents LPS-Induced TNF-alpha Expression in Cardiac Myocytes Through Inhibiting NF-kappa B Signaling Pathway. Lihua Lv,Linhua Lv,Yubi Zhang. Inflammation . 2011Lv. L,Zhang, Y.,Kong, Q.Luteolin prevents LPS-induced TNF-a expression in cardiac myocytes through inhibit...
It was demonstrated that uric acid induced the expression of TNF-alpha via the ROS-MAPK-NF-kappa B signaling pathway in VSMCs, providing novel evidence supporting the pro-inflammatory and pro-atherosclerotic effects of uric acid.Tang, LirongXu, Yu'eWei, YingHe, Xu...
TNF-alpha/NF-kappa B signaling pathwayInflammationApoptosisARTHRITISTHERAPYPurpose: To study the influence of etanercept on diabetic retinopathy in rats via tumor necrosis factor alpha (TNF-alpha)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) signaling pathway. Methods: ...