Zhang X, Zhang Y, Zhou P, et al. Down-regulated cylindromatosis enhances NF-κB activation and aggravates inflammation in HBV-ACLF patients. Emerg Microbes Infect. 2022;11(1):1586-1601. doi:10.1080/22221751.2022.2077128 Role and mechanisms of the NF-ĸB signaling pathway in various developm...
NF-κB 激活通过两个主要信号通路发生：经典和非经典 NF-κB 信号通路，两种通路具有不同的激活机制。■ 经典 NF-κB 通路在暴露于促炎信号后数分钟内被激活。它由含有 NEMO (也称为 IKKγ，NF-κB 信号必需调节剂) 的 IKK 复合物的激活介导，后者又指定经典的 IκB 进行降解，随后释放 NF-κB 二聚体用于...
(Chen Y, Wang D, Peng H, et al. Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression.Mol Canc...
本篇内容主要研究揭示外泌体miR-1910-3p在乳腺癌中促增殖和转移作用,并确定血清外泌体miR-1910-3p作为乳腺癌诊断分子标记物的临床诊断价值。 Exosomal miR-1910-3p Promotes Proliferation, Metastasis, and Autophagy of Breast Cancer ...
NF-kB and SAT3 signaling pathways collaboratively link inflammation to cancer Protein & Cell. 2013, 4 : 176-185.12 Bcn-Neriai Y t Karin M Inflammalion meets cancer, with NF-kB as the matchmaker. Nat Immunol, 201 lt 12 : 715 -723.13 Ijdpcz-Alonso I, Aguirre A, Gonz61ez-L6pez A, ...
[1]. Dimitrakopoulos, F.D., et al., The Fire Within: NF-κB Involvement in Non–Small Cell Lung Cancer. Cancer Research, 2020. 80(19): p. 4025-4036.[2]. Parvatiyar, K., et al., A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling. Nat ...
SARS-CoV-2, liver disease, and cancer demonstrating the versatility of NF-κB research. High-impact papers like "Collagenolysis-dependent DDR1 signaling in pancreatic cancer" and "Targeting UbcH5c for pancreatic cancer treatment" showcase the translational potential of NF-κB pathway ...
The transcription factor nuclear factor-κB (NF-kB) was discovered 30 years ago and plays an important role in carcinogenesis, cell growth, apoptosis and in immune and inflammatory responses. In the resting state, homodimers or heterodimers of NF-κB family are prevented from binding to DNA as...
[12]Zhang H, Chen Z, Miranda RN, et al. TG2 and NF-kB signaling coordinates the survival of mantle cell lymphoma cells via IL-6-mediated autophagy [J]. Cancer Research,2016,76(21):6410-6423. [13]Peng J, Yang Q, Li AF, et al. Tet methylcytosine dioxygenase 2 inhibits atherosclerosi...
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