TNF- α (31-45), human is human tumor necrosis factor- α The peptide fragment contains the 31st to 45th amino acids in the sequence. TNF- α (31-45), human is an effective NF-kB pathway activator and a pro-inflammatory cytokine that can induce necrosis or apoptosis. TNF α Stimulatin...
NF-kB binds to specific consensus DNA sequences (5'GGGACTTTCC-3') found in various genes, thereby modulating their transcription. The activation process is facilitated by the IkB kinase complex, which consists of at least three proteins: IKK1/IKKa, IKK2/IKKb, and IKK3/IKKg. T...
[SEQUENCE ] [ IDENTIFICATION ] [ IMPORTANT NOTE ] The kit is designed for research use only, we will not be responsible for any issue if the kit was used in clinical diagnostic or any other procedures. 特别提示:本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!以实际收货产品...
(RHD) of NF-kB and interfere with its nuclear localization sequence (NLS) function. These inhibitor proteins, which include IkBa, IkBb and IkBg, contain 6–7 ankyrin repeats that mediate binding to the RHD. These repeats are also present in the C-terminal halves of the NF-kB2/p100 and...
which is followed by its ubiquitination and subsequent degradation. This results in the exposure of the nuclear localization signals (NLS) on NF-kB subunits and the subsequent translocation of the molecule to the nucleus. In the nucleus, NF-kB binds with a consensus sequence (5'GGGACTTTCC-3'...
In the nucleus, NF-kB binds with a consensus sequence (5'GGGACTTTCC-3') of various genes and thus activates their transcription. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins; IKK1/IKKa, IKK2/IKKb, and IKK3/IKKg. These enzymes phosphorylate ...
2 NF-KB信号通路NF_KB介导的信号通路足一个抗凋亡的信号通路,经典的NF_KB信号通路如下:未激活的NF-KB以二聚体的形式存在 于细胞质中,与KB抑制分子(inhibitors of KB,IKBs)结合,掩盖 了NF-KB中的核定位序列(nuclear localization sequence, NLS),阻止NF-KB向核移位。研究发现所有的激活NF-KB的 信号通路都通过...
NFKB抑制因子(NKRF)重组蛋白SEQUENCES The sequence of the target protein is listed below.MEKILQMAEG IDIGEMPSYD LVLSKPSKGQ KRHLSTCDGQ NPPKKQAGSK FHARPRFEPV HFVASSSKDE RQEDPYGPQT KEVNEQTHFA SMPRDIYQDY TQDSFSIQDG NSQYCDSSGF ILTKDQPVTA NMYFDSGNPA PSTTSQQANS QSTPEPSPSQ TFPESVVAEK QYFIEKLT...
This liberation allows NF-κB to translocate to the nucleus, where it binds to specific DNA sequences and regulates the expression of genes involved in immune and inflammatory responses. NF-κB信号通路在调节细胞对各种刺激的反应中起着关键作用,这些刺激包括压力、炎症和免疫反应等。这一通路的核心是...