http://upload.***.org/wikipedia/commons/5/5e/NFKB_mechanism_of_action.png 因此对NF-kB的研究...
To evaluate the mechanism of action of Minnelide, we used 2 human tumor-derived pancreatic cancer cell lines: MIA PaCa-2, derived from a primary tumor, and S2-VP10, derived from a liver metastasis. In both of these cell lines, triptolide treatment decreases RNA and protein levels of p50 ...
However, the molecular mechanism of action against inflammation in RAW 264.7 cells is only partially explored. Quercetin effect on LPS-induced gene and protein expressions of inflammatory mediators and cytokines...年份: 2017 收藏 引用 批量引用 报错 分享 ...
Mechanism of Action of a Novel Latent Membrane Protein-1 Dominant Negative We have demonstrated that it does not sequester the downstream signaling molecule, TRAF2, but instead binds LMP1 and interferes with its ability to bind ... P Brennan,JE Floettmann,A Mehl,... - 《Journal of Biological...
The sesquiterpene lactone helenalin is a potent anti-inflammatory drug whose molecular mechanism of action remains unclear despite numerous investigations... Lyss,G. - 《Journal of Biological Chemistry》 被引量: 708发表: 1998年 The ISME Journal - Quorum quenching quandary: resistance to antivirulence...
PDTC is a highly interesting compound with a dual mechanism of action as an antioxidant and a specific inhibitor of the NF-kB (Nurmi et al, 2006; Soerensen et al, 2009). PDTC reversibly inhibits the nuclear translocation of NF-kB by decreasing the concentration of metal ions and hydroxyl ...
The effects of walnut oil on wound healing and skin injury repair was observed in Sprague-Dawley (SD) rats, and mechanism of action was investigated. Normal SD rats were divided into an experimental group and a control group. Each group was observed at4 time points (day [D]3, D7 D14,...
Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic Mechanism of Action Metastasis requires coordinated expression of multiple genetic cassettes, often via epigenetic regulation of gene transcription. BRMS1 blocks metastasis, b... DR Welch,CA Manton...
Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues. BACKGROUND: Epothilones are 16-member ring macrolides with antimicrotubule activity that share a similar mechanism of action to the taxanes but have demons... P Fumoleau,B Coudert,N Is...
Persistent activation of NF-kB by the Tax transforming protein of HTLV-1: hijacking cellular IkB kinases functions, suggesting a distinct mechanism of Tax action on each host signaling pathway (Semmes and Jeang, 1992; Smith and Greene, 1990). Such mutants have... SC Sun,DW Ballard 被引量:...