NK cell activation by dendrit-ic cell vaccine : a mechanism of action for clinical activity [ J ]. Cancer Immunol [mmunother, 2006, 55 ( 9 ) : 1122-1131.NK cell activation by dendritic cell vaccine: a mechanism of action for clinical activity[J] . Takuya Osada,Timothy Clay,Amy Hobeika...
近日,希望之城的科学家们在《Cancer Discovery》杂志上发表了一篇名为“The mechanism of anti-PD-L1 antibody efficacy against PD-L1 negative tumors identifies NK cells expressing PD-L1 as a cytolytic effector”的研究论文。该研究通过抗PD-L1单抗激活表达PD-L1的NK(PD-L1+NK)细胞,发现了一种独立于PD-1...
If an NK cell expressing PD-L1 is treated with a PD-L1 antibody, the interaction activates PD-L1+ NK cells to control the growth of tumors by killing those tumors and by the secretion of cytokines. This demonstrates a novel mechanism of action that provides a significant role for the NK ...
自然杀伤细胞(NK Cells)通过释放穿孔素和颗粒酶等细胞毒性物质以及诱导细胞凋亡等途径发挥抗感染和清除癌变细胞的功能,是维持机体免疫稳态的重要成员。外泌体(Exo)是介导细胞间通讯的重要介质,通过递送生物活性分子如脂质、蛋白质和核酸从...
Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic activity, have recently attracted attention as potential anticancer therapeutics. While NK cells mediate encouraging responses in patients with leukemia, the therapeutic effects of NK cell infusion in patients with solid...
The tumor-guided expression of such receptors on tumor-reactive effector cells and their ligands on tumor cells results in a potent, primary mechanism of evasion from anti-tumor immunity. By disrupting the receptor-ligand interaction, ICI unleash T and/or NK cells and restore the anti-tumor ...
Moreover, NK cell numbers, percentages, maturation and functions were preserved in the presence of Artemisinin in vitro, suggesting that Artemisinin displays detrimental effects only on tumor cells but not on immune cells. These data reveal a novel anti-tumor mechanism of Artemisinin and demonstrate ...
Surface phenotype, anatomical localization and function of different NK cell subsets 2.4 Role of NK cells in the control of tumors The impressive advances obtained in the last 15-20 years in the knowledge of the mechanism of action of NK cells and of their regulation, have been fuelled by ...
Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action (MOA) of several therapeutic antibody drugs and evaluation in ADCC bioassays is important in antibody drug development and maintenance. Three types of effector cells now routinely used in bioassay evaluation of ADCC...
21. NK cell cytotoxicity against cancer cells involves the secretion of perforin, granzyme B22,23,24, and pro-inflammatory cytokines, such as tumor necrosis factor-α and interferon (IFN-γ)25,26,27. As such, NK cell immunotherapy appears as a promising, novel treatment approach for brain ...