NK cell activation by dendritic cell vaccine: a mechanism of action for clinical activity. Cancer Immunol Immunother. 2005;5:1-10.Osada T, Clay T, Hobeika A, Lyerly HK, Morse MA. NK cell activation by den- dritic cell vaccine: a mechanism of action for clinical activity. Cancer Immunol...
As a vital cell type in immune system and infiltrating cells in ischemic brain, NK cells can bridge the crosstalk between immune system and nervous system in stroke setting. The mechanism of action of NK cells is complicated, involving direct and indirect actions. NK cells are closely associated...
If an NK cell expressing PD-L1 is treated with a PD-L1 antibody, the interaction activates PD-L1+ NK cells to control the growth of tumors by killing those tumors and by the secretion of cytokines. This demonstrates a novel mechanism of action that provides a significant role for the NK ...
Interestingly, the mechanism of action involves triggering and relief of inhibition, in T and NK cells respectively, by a single ligand (Figure 2C). This model is particularly relevant to the present issue, since tumor-rejecting T and NK cells are both highly lytic, and rapidly (within a ...
近日,希望之城的科学家们在《Cancer Discovery》杂志上发表了一篇名为“The mechanism of anti-PD-L1 antibody efficacy against PD-L1 negative tumors identifies NK cells expressing PD-L1 as a cytolytic effector”的研究论文。该研究通过抗PD-L1单抗激活表达PD-L1的NK(PD-L1+NK)细胞,发现了一种独立于PD-...
cells in the development of MM and their uses in immunotherapies T Dosani1, M Carlsten2, I Maric3 and O Landgren4 As vast strides are being made in the management and treatment of multiple myeloma (MM), recent interests are increasingly focusing on understanding the development of the disease...
自然杀伤细胞(NK Cells)通过释放穿孔素和颗粒酶等细胞毒性物质以及诱导细胞凋亡等途径发挥抗感染和清除癌变细胞的功能,是维持机体免疫稳态的重要成员。外泌体(Exo)是介导细胞间通讯的重要介质,通过递送生物活性分子如脂质、蛋白质和核酸从...
ostertagi. Therefore, a possible mechanism of action for NK cells against O. ostertagi could be the recognition of antibody-sequestered nASP and subsequent antibody mediated degranulation. Since NK cells are known to express granzyme B, perforin and granulysin, this could be an interesting link with...
Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic activity, have recently attracted attention as potential anticancer therapeutics. While NK cells mediate encouraging responses in patients with leukemia, the therapeuti
Complement-dependent cytotoxicity (CDC) is also an important mechanism of action for monoclonal antibodies, whereby they activate the complement system, leading to the specific lysis of target cells. Cancer cells express various cell surface proteins that interact with inhibitory receptors on immune ...