thalidomide等IMiD药物通过抑制NF-κB下游的转录功能来发挥作用。 单克隆抗体,包括抗PD-L1、抗IL-1和抗TNF-α,阻断配体和各自受体的结合,抑制其生物学效应。蛋白酶体抑制剂包括Bortezomib,Carfilzomib,Ixazomib和 Lactacystin,其作用是阻止最终导致细胞凋亡和细胞死亡的蛋白质降解。Tacrolimus抑制钙调磷酸酶的蛋白磷酸酶活性...
而HK2作为一种蛋白激酶可以使肿瘤细胞中IkBa磷酸化,导致IkBa降解和NF-kB活化依赖性的PD-L1表达增加,以逃避肿瘤免疫。本研究阐明了有氧糖酵解介导的PD-L1表达上调的新机制,并强调了HK2作为葡萄糖传感器和蛋白激酶在调节肿瘤免疫逃避中的作用。
PD-L1 (programmed cell death ligand 1) but not PD-L2 nor Galectin 9 or Death receptor (DR4, DR5 and Fas) and ligands (FasL and TRAIL) expression was up-regulated during cytokine-driven EMT in a reversible manner. Moreover PD-L1 is overexpressed in VIMENTIN positive NSCLC tissues. We ...
内PKC⁃α㊁磷酸化NF⁃κB 水平增加,转染PD⁃L1siRNA 后大鼠PMN 内PKC⁃α㊁磷酸化NF⁃κB 水显著下降(P <0.05)㊂结论:脓毒血症患者体内PMN 凋亡延迟,与PD⁃L1表达呈显著负相关,提示PD⁃L1可能是调控脓毒血症PMN 延迟凋亡的重要分子㊂在脓毒血症大鼠模型中,沉默PD⁃L1基因能够改善脓毒...
单克隆抗体，包括抗PD-L1、抗IL-1和抗TNF-α，阻断配体和各自受体的结合，抑制其生物学效应。蛋白酶...
PD-L1 induced immune suppression has increasingly gained attention in clinical management of cancer; however, to date, the clinical significance and regulatory mechanisms of PD-L1 in meningioma is not yet fully characterized. We sought to characterize PD-L1 expression in meningioma and elucidate its ...
Cordycepin inhibits glioma growth by downregulating PD-L1 expression via the NOD-like receptor/NFKB1/STAT1 axis Authors - Jing Chen View Article human IF Circ Res Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm Authors - Ying Wen View Article mouse IF,WB Cell Com...
Cordycepin inhibits glioma growth by downregulating PD-L1 expression via the NOD-like receptor/NFKB1/STAT1 axis Authors - Jing Chen View Article human IF Circ Res Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm Authors - Ying Wen View Article mouse IF,WB Cell Com...
进一步对亚组分析发现,直肠肿瘤组织PD-L1综合阳性评分高分患者可能获益更加显著。综合阳性高评分的肿瘤免疫相关通路激活更显著,包括炎性反应、IL6-JAK-STAT3、TNFa-NFKB、IL2-STAT5信号通路,并具有更高的免疫评分和免疫细胞估算丰度,为分层治疗提供了线索。 在对比治疗效果时发现,未实现完全缓解的肿瘤组织相较于达到完...
例如,可以施用的第二治疗剂选自btk(布鲁顿氏酪氨酸激酶)抑制剂诸如依鲁替尼、syk抑制剂、pkc抑制剂、pi3k通路抑制剂、bcl家族抑制剂、jak抑制剂、pim激酶抑制剂、利妥昔单抗或其他b细胞抗原结合抗体,以及免疫细胞重定向剂(例如,博纳吐单抗或car t细胞)和免疫调节剂诸如达雷木单抗、抗pd1抗体和抗pd-l1抗体。