单克隆抗体,包括抗PD-L1、抗IL-1和抗TNF-α,阻断配体和各自受体的结合,抑制其生物学效应。蛋白酶体抑制剂包括Bortezomib,Carfilzomib,Ixazomib和 Lactacystin,其作用是阻止最终导致细胞凋亡和细胞死亡的蛋白质降解。Tacrolimus抑制钙调磷酸酶的蛋白磷酸酶活性,阻止NFAT的核易位,从而抑制T细胞的活化。IκBα超抑制因子抑制...
而HK2作为一种蛋白激酶可以使肿瘤细胞中IkBa磷酸化,导致IkBa降解和NF-kB活化依赖性的PD-L1表达增加,以逃避肿瘤免疫。本研究阐明了有氧糖酵解介导的PD-L1表达上调的新机制,并强调了HK2作为葡萄糖传感器和蛋白激酶在调节肿瘤免疫逃避中的作用。
PD-L1 (programmed cell death ligand 1) but not PD-L2 nor Galectin 9 or Death receptor (DR4, DR5 and Fas) and ligands (FasL and TRAIL) expression was up-regulated during cytokine-driven EMT in a reversible manner. Moreover PD-L1 is overexpressed in VIMENTIN positive NSCLC tissues. We ...
内PKC⁃α㊁磷酸化NF⁃κB 水平增加,转染PD⁃L1siRNA 后大鼠PMN 内PKC⁃α㊁磷酸化NF⁃κB 水显著下降(P <0.05)㊂结论:脓毒血症患者体内PMN 凋亡延迟,与PD⁃L1表达呈显著负相关,提示PD⁃L1可能是调控脓毒血症PMN 延迟凋亡的重要分子㊂在脓毒血症大鼠模型中,沉默PD⁃L1基因能够改善脓毒...
单克隆抗体，包括抗PD-L1、抗IL-1和抗TNF-α，阻断配体和各自受体的结合，抑制其生物学效应。蛋白酶...
Cordycepin inhibits glioma growth by downregulating PD-L1 expression via the NOD-like receptor/NFKB1/STAT1 axis Authors - Jing Chen View Article human IF Circ Res Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm Authors - Ying Wen View Article mouse IF,WB Cell Com...
PD-L1 induced immune suppression has increasingly gained attention in clinical management of cancer; however, to date, the clinical significance and regulatory mechanisms of PD-L1 in meningioma is not yet fully characterized. We sought to characterize PD-L1 expression in meningioma and elucidate its ...
进一步对亚组分析发现,直肠肿瘤组织PD-L1综合阳性评分高分患者可能获益更加显著。综合阳性高评分的肿瘤免疫相关通路激活更显著,包括炎性反应、IL6-JAK-STAT3、TNFa-NFKB、IL2-STAT5信号通路,并具有更高的免疫评分和免疫细胞估算丰度,为分层治疗提供了线索。 在对比治疗效果时发现,未实现完全缓解的肿瘤组织相较于达到完...
Cordycepin inhibits glioma growth by downregulating PD-L1 expression via the NOD-like receptor/NFKB1/STAT1 axis Authors - Jing Chen View Article human IF Circ Res Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm Authors - Ying Wen View Article mouse IF,WB Cell Com...
(例如卡铂、吉西他滨、紫杉醇)、靶向剂(例如egfr抑制剂,诸如吉非替尼、埃罗替尼、阿法替尼和奥昔替尼,以及alk抑制剂,诸如克唑替尼、西利替尼和阿来替尼)、单克隆抗体(例如抗vegf抗体,诸如贝伐单抗,以及抗egfr抗体,诸如耐昔妥珠单抗)和免疫治疗剂(例如抗pd-1抗体,诸如纳武单抗和派姆单抗,以及抗pd-l1抗体,...