在小鼠肿瘤模型中也证明,用PD-1抗体进行免疫治疗的同时,激活NF-kB信号通路进行联合治疗,可以显著提高免疫治疗的效果。 非经典的NF-κB通路富含能生成IL-12的树突细胞,这一通路在抗PD-1治疗中是必须的,并且治疗过程中激动该通路能够增强肿瘤侵润树突细胞的IL-12生成。 小结 通过研究肿瘤微环境下免疫治疗的直接与...
Enhanced anti-tumor effects of the PD-1/PD-L1 blockade by combining a highly absorptive form of NF-kB/STAT3 inhibitor curcumin. J. Immunother. Cancer 2, 210.Hayakawa T, sugiyama J, Yaguchi T, imaizumi A and Kawakami Y: Enhanced anti-tumor effects of the pD1/pDL1 blockade by combining ...
其中nfkb细胞信号传导途径在细胞中的活性通过包括如下步骤的方法推断或可通过包括如下步骤的方法推断:接收nfkb细胞信号传导途径的一个或多个、优选六个或更多个靶基因的表达水平,确定nfkb转录因子(tf)元件的水平,所述nfkb tf元件控制nfkb细胞信号传导途径的...
1.一种确定含有具有活跃NFkB细胞信号传导途径的细胞的细胞样品中活跃NFkB细胞信号传导途径的细胞功能的方法,所述方法包括: 确定选自由BCL2、BCL2L1、CCND2、SKP2、CSF1、NOX1和SERPINE2组成的组1中的两个或更多个基因的表达水平;和 确定选自由CYP27B1、IGHE/IGHG1组成的组2中的两个基因的表达水平;和 确定...
本发明公开了ATM抑制剂和NEMO抑制剂组合在制备抑制PDL1的表达的药物中的应用.以及活性成分包括ATM抑制剂和NEMO抑制剂的抑制PDL1的表达的抗肿瘤的联合用药物.本发明所述的ATM和NEMO抑制剂与CPT联合用药能够降低肿瘤细胞PDL1蛋白质表达水平,减少肿瘤细胞表面... 邵兰,王宗任 被引量: 0发表: 2021年 加载更多来源...
1; MDSC: Myeloid Derived Suppressor Cells; MITF: Melanocyte Inducing Transcription Factor; mPGES1: Microsomal Prostaglandin E Synthase-1; mTOR: Mammalian Target Of Rapamycin; NFkB: Nuclear Factor kappa-light-chain-enhancer of activated B cells; PDL1: Programmed Death- Ligand 1; PGE2: Prostaglandin...
Bioinformatic analysis (KEGG, GO analysis) on the dataset GSW2803868 (the mRNA sequencing performed on osteolysis model in vitro) from GEO indicated that NF-kB signaling is one of the key pathways to wear particle-induced osteolysis (Fig. 5ÃC). Studies revealed that TAB3 regulates the NF...
The genes IKBKB, IRAK3, IRF5, MAP2K4 (MEK4), MAPK14 (p38), MAPK8 (JNK1) and NFKB1 (p50) were upregulated not only in both cell types, but also after infection with whole bacteria of P. gingivalis W83 as well as with the membrane fraction. The cytosolic fraction didn’t induce...
Download: Download high-res image (342KB) Download: Download full-size image Figure 1. NQBS chemical structure (A and B) (A) General synthetic pathways for the preparation of NQBS; (B) chemical structure of representative compounds (CU-O42, CU-O47, CU-O75, and CU-O102) The effect ...
Recent functional and genomic studies have implicated NF-κB pathway activation (e.g.,TNFAIP3, MYD88) and immune evasion (e.g.,PDL1/CD274, PDL2/PDCD1LG2) in the pathogenesis of EBV-associated lymphomas4,5,6,7. However, there remains little understanding of how somatic genetic aberrations ...