2,《珠江肿瘤》https://mp.weixin.qq.com/s/_QzgYgocwONAR_PldoqnjQ 3,Targe ting the NF -kB Pathway inCancer Therapy.Derek J. Erstad,MDa, James C. Cusack Jr,MDb,(2013) 705–746 公众号已经建立实名“德兰系肿瘤免疫精英阅读荟”交流微信群,可以添加小...
因此,作为抗癌治疗的靶标,NF-κB是制药公司中许多活跃研究的主题。 今天,以文章“lncRNA-PLACT1 sustains activation of NF-κBpathway through a positive feedback loopwith IκBα/E2F1 axis in pancreatic cancer”为例,了解NF-κB信号通路在胰腺癌中的发挥...
Mol Cancer(IF :46) 研究结果表明,抑制UbcH5c是治疗胰腺癌的一种新而有效的策略,DHPO代表了一类新的UbcH5c抑制剂,抑制UbcH5c介导的IκBα降解和NF-κB活化,这对其抗癌活性至关重要,并可能被进一步开发为抗胰腺癌治疗剂。 Qi S, Guan X, Zhang J, et al. Targeting E2 ubiquitin-conjugating enzyme UbcH5...
TGF-β/PI3K/AKT/mTOR/NF-kB pathway. Clinicopathological features in prostate cancerAKTNF-kBPI3KProstate cancerTGF-BmTORProstate cancer is one of the most common cancers in the male population. The objective of this investigation was to study the relationship of components of transforming growth ...
NF-kBinducing kinase (NIK), which is essential for the activation of the noncanonical NF-kB pathway, regulates diverse processes in immunity, development, and disease. Although recent studies have elucidated important functions of NIK in adaptive immune cells and cancer cell metabolism, the role of...
TNF- α (31-45), human is an effective NF-kB pathway activator and a pro-inflammatory cytokine that can induce necrosis or apoptosis. TNF α Stimulating NF through TNFR2- κ B pathway promotes cancer growth, invasion, and metastasis. Purity (HPLC) ≥98.0% Single impurity≤2% Peptide ...
Emerging evidence suggests that the members of the tripartite motif (TRIM) family play a crucial role in cancer development and progression. The purpose of the study was to explore TRIM52's role in tumorigenesis and its potential molecular mechanism in o
[5] Magne N,Toillon RA, Bottero V, et al. NFkappaB modu-lation and ionizing radiation : mechanisms and future direc tions for cancer treatment[Jl. Cancer, 2006 , 231 (2) : 158- 168. [6] Scheidereit C. IkappaB kinase complexes : gateways to NF- kappaB activation and transc[x]rip...
SARS-CoV-2, liver disease, and cancer demonstrating the versatility of NF-κB research. High-impact papers like "Collagenolysis-dependent DDR1 signaling in pancreatic cancer" and "Targeting UbcH5c for pancreatic cancer treatment" showcase the translational potential of NF-κB pathway ...
5.2. Gastric Cancer Drivers of gastric cancer (GC) include poor diet, obesity, and chronic infection. One of the main infection-driven gastric cancers is caused by Helicobacter pylori. Helicobacter Pylori produces a number of virulence factors able to activate the NF-κB pathway, which in turn ...