由:美国宾夕法尼亚州费城德雷塞尔大学医学院生物化学与分子生物学系,癌症信号和微环境计划,Fox Chase 癌症中心, Dorothy Benton,Hoi Yee Chow,Sofiia Karchugina,Jonathan Chernoff 等人共同撰写题为《Synergistic effect of PAK and Hipp...
Liu H, Muzikansky A, Plotkin SR, Stankovic KM, Jain RK, Xu L. Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models. Proc Natl Acad Sci U S A, 2018, 115(9): E
Intriguingly, RAS is thought to be associated with the Hippo pathway. On the one hand, RAS is influenced by the Hippo pathway, which is a transcriptional target of YAP-TEAD1 and includes three kinds of RASs. Silencing of YAP in Cal62 (KRAS-G12R,NF2-null) cells decreased the mRNA levels...
Neurofibromatosis 2 (NF2) tumor suppressor protein-merlin is involved in Hippo/SWH signaling pathway that associated with tumor suppression by restricting proliferation and promoting apoptosis. It has been reported that merlin can change to phosphorylation form which inactivates merlin tumor suppressive abil...
. These results suggested that the process of follicular atresia inBnc1tr/trandBnc1loxP/loxP,Gdf9-Cre (+) mice was mediated not by apoptosis but rather by a nonapoptotic cell death pathway. Fig. 3:Bnc1mutation induces follicular atresia through nonapoptotic cell death....
④ 视神经胶质瘤（optic pathway glioma，OPG）；⑤ 2个或以上Lisch结节（虹膜错构瘤）；⑥ 特征性骨...
(E10.5-E18.5).#In contrast to many other organs in which the Nf2/Hippo pathway activity restrains growth and cell proliferation and as a result, loss of Nf2 decreases Hippo pathway activity and promotes an enlarged organ development, here we report our observations of distinct, tongue region-...
背景介绍:Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably ...
Thus, the degradation of mutant forms of Sch by the ubiquitin-proteasome system reported herein is a functional pathway in Schwann cells, the primary NF2-affected lineage. In addition, in the sciatic nerves of these transgenic mice, the level of SchΔ39–121 was found to be similar to that...
Fig. 2. (A) Merlin activates the Hippo pathway to suppress YAP/TAZ through regulation of core kinase components at the plasma membrane, through inhibition of the CRL4DCAF1 E3 ubiquitin ligase in the nucleus, and by regulating cell junction-associated proteins that modulate Hippo signaling. (1)...