2022年10月,浙江大学医学院附属妇产科医院张丹教授团队在Nature子刊Nature Communications上发文:BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency。文章中,作者通过建立Basonuclin 1 (BNC1...
由于NF2是 Hippo-YAP通路中的关键调节因子,且YAP/TAZ是TBK1的有效抑制因子。研究人员探究了NF2基因敲除细胞中YAP/TAZ的磷酸化状态,并观察到NF2的缺乏降低了YAP S127的磷酸化水平。然而,YAP/TAZ的敲除显著增强了TBK1的激活、并消除了NF2缺乏对核酸传感的...
addition, ovarian single-cell RNA sequencing has revealed an association between oocyte loss and ferroptosis around the perinatal period30. However, the role of ferroptosis in POI remains unknown. In this work, we find that BNC1 is involved in lipid metabolism and maintaining redox homeostasis in ...
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus. Cancer Cell 26, 48–60 (2014). Article Google Scholar Dupont, S. et al. Role of YAP/TAZ in mechanotransduction. Nature 474, 179–183 (2011). ...
Specifically, at E12.5Nf2cKOmutants had a decreased level of Hippo signalling transcription factor Yes-associated protein (Yap), Yap target genes and cell proliferation anteriorly, while having an increased Yap, Yap target genes and cell proliferation posteriorly, which lead to a tip-pointed and ...
KAT2B inhibits CCA cell growth via interaction with SP1 to promote the expression of NF2 and thus activate Hippo pathway, which leads to subsequent inhibition of the oncogenic YAP signaling. **P < 0.01 Full size image SP1 is a zinc finger transcription factor which binds to GC-rich ...
NF2 Hippo pathway YAP TAZ ROS RAF-MEK-ERK pathway Introduction The Neurofibromatosis Type 2 (NF2) gene, which encodes a protein called Moesin-ezrin-radaxin-like protein (Merlin), is a bona fide tumor suppressor (Petrilli and Fernández-Valle, 2016). Deletions or loss-of-function mutations of...
Fig. 2. (A) Merlin activates the Hippo pathway to suppress YAP/TAZ through regulation of core kinase components at the plasma membrane, through inhibition of the CRL4DCAF1 E3 ubiquitin ligase in the nucleus, and by regulating cell junction-associated proteins that modulate Hippo signaling. (1)...
Neurofibromatosis Type II (NFII) is a genetic condition caused by loss of thegene, resulting in activation of the YAP/TAZ pathway and recurrent Schwann cell tumors, as well as meningiomas and ependymomas. Unfortunately, few pharmacological options are available for NFII. Here, we undertake a ...
由于Hippo通路也在NF2缺陷细胞中被激活,因此最近以YAP-TEAD结合抑制剂的形式开发了几种Hippo通路抑制剂。这些抑制剂可阻止促增殖和抗凋亡Hippo通路效应子的激活。在这项研究中,我们发现PAK抑制减缓细胞增殖,而TEAD抑制促进凋亡细胞死亡。最...