在人神经鞘瘤细胞中,siRNA 对 Hippo通路的下游效应子YAP进行基因消融阻止了生长(图2A和2B),这表明该通路的小分子抑制剂可能是有益的。由于YAP缺乏DNA结合域,因此需要与细胞核内的TEAD家族蛋白之一结合以促进Hippo靶基因的转录。YAP和TE...
这些研究表明,NF2对于胞浆中核酸的有效传感是至关重要的。由于NF2是 Hippo-YAP通路中的关键调节因子,且YAP/TAZ是TBK1的有效抑制因子。研究人员探究了NF2基因敲除细胞中YAP/TAZ的磷酸化状态,并观察到NF2的缺乏降低了YAP S127的磷酸化水平。然而,YAP/TAZ...
The Hippo pathway plays a crucial role in cell proliferation and differentiation during tumorigenesis, tissue homeostasis and early embryogenesis. Scaffold proteins from the ezrin-radixin-moesin (ERM) family, including neurofibromin 2 (NF2; Merlin), regulate the Hippo pathway through cell polarity....
LncRNA-MIAT activates hepatic stellate cells via regulating Hippo pathway and epithelial-to-mesenchymal transition Article Open access 18 March 2023 Introduction Liver fibrosis, the common process of most chronic liver diseases, will eventually progress to cirrhosis, resulting in high morbidity as well...
Background Information Neurofibromatosis 2 (NF2) tumor suppressor protein-merlin is involved in Hippo/SWH signaling pathway that associated with tumor suppression by restricting proliferation and promoting apoptosis. It has been reported that merlin can change to phosphorylation form which inactivates merlin...
(NF2)-YAP-Hippo pathway20,21,22. NF2 and/or LATS2 mutations lead to increased nuclear localization of YAP and promote proliferation and migration of cancer cells23,24. Some studies have reported that Hippo-YAP1 regulates primordial follicular activation25,26. However, activation of YAP can ...
背景介绍:Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably ...
Fig. 2. (A) Merlin activates the Hippo pathway to suppress YAP/TAZ through regulation of core kinase components at the plasma membrane, through inhibition of the CRL4DCAF1 E3 ubiquitin ligase in the nucleus, and by regulating cell junction-associated proteins that modulate Hippo signaling. (1)...
KAT2B inhibits CCA cell growth via interaction with SP1 to promote the expression of NF2 and thus activate Hippo pathway, which leads to subsequent inhibition of the oncogenic YAP signaling. **P < 0.01 Full size image SP1 is a zinc finger transcription factor which binds to GC-rich ...
In addition, we have observed that Merlin controls, through CRL4DCAF1, the expression of genes involved in receptor tyrosine kinase and adhesion signaling, intracellular trafficking, and a subset of Hippo pathway target genes. The ability of CRL4DCAF1 to regulate these genes may explain some of...