The Hippo pathway was first discovered inDrosophila melanogasterand has been studied for the past 20 years. A timeline of essential discoveries and processes of the Hippo pathway is shown in Fig.1. In mammals, the Hippo pathway is composed of several key components, including mammalian STE20-lik...
which may further promote pathway activation through a currently undefined mechanism. Interestingly, Hippo signaling appears to have a high degree of evolutionary conservation from flies to humans as mammalian orthologs exist for each fly counterpart and generally function in a similar manner. However, ...
Guan’s lab and others havepreviously established the key signaling components of the pathway, but its controlor braking mechanism – how the pathway shuts off at the proper time – had notbeen identified until now. “It was already known that YAP and TAZ, twotranscription co-activators, work ...
Zhang L,Yue T,Jiang J.Hippo signaling pathway and organ size control. Fly (Austin) . 2009Zhang L, Yue T, Jiang J. Hippo signaling pathway and organ size control. Fly (Austin) 2009, 3: 68-73.Zhang L,Yue T,Jiang J.Hippo signaling pathway and organ size control. Fly (Austin) . ...
Accumulated evidence suggests that the Hippo signaling pathway plays crucial roles in mammary gland development and breast cancer. Key components of the Hippo pathway regulate breast epithelial cell proliferation, migration, invasion, and stemness. Additionally, the Hippo pathway regulates breast tumor grow...
the level of Yki inpatched(ptc) mutant cells. Ptc is a key negative regulator of the Hedgehog pathway. The Yki level was significantly increased inptcmutant cells in follicle cell precursors (Fig.4A). This result confirmed that the Hippo pathway acts downstream of the Hedgehog signaling in the...
M. The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. Cell 126, 767–774 (2006). 39. Robinson, B. S., Huang, J., Hong, Y. & Moberg, K. H. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-...
The Hippo signaling pathway acts upon the Yorkie transcriptional activator to control tissue growth in Drosophila. Activated Yorkie drives growth by stimulating cell proliferation and inhibiting apoptosis, but how it achieves this is not understood. Yorkie is known to activate Cyclin E (CycE) and the...
The Hippo signaling pathway functions through Yorkie to control tissue growth and homeostasis. How this pathway regulates non-developmental processes remains largely unexplored. Here, we report an essential role for Hippo signaling in innate immunity whereby Yorkie directly regulates the transcription of th...
To study the transcriptional regulation of dilp8 by Yki in vivo, we next generated transgenic fly lines carrying constructs harbouring either the full dilp8 promoter (dilp8-full-prom), dilp8- PF, dilp8-PFD123 or intron 1 of the dilp8 gene used as a negative control, all fused to the ...