NF-kB ReviewZazzeroni, FrancescaFranzoso, Guido
NF-κB 激活通过两个主要信号通路发生：经典和非经典 NF-κB 信号通路，两种通路具有不同的激活机制。■ 经典 NF-κB 通路在暴露于促炎信号后数分钟内被激活。它由含有 NEMO (也称为 IKKγ，NF-κB 信号必需调节剂) 的 IKK 复合物的激活介导，后者又指定经典的 IκB 进行降解，随后释放 NF-κB 二聚体用于...
在TNF诱导的炎症应激下,与野生型NFKB1不同,AS-NFKB1抑制了炎症基因的表达,提示其可能具有抗炎保护作用 (under review, Nature Communication)。 基于此,研究者进一步探讨了NFKB1 rs230511与PV和ET患者中的炎症标志物以及对Ropeg治疗...
Pattabiraman N,Zhou JN,et al.Cyclin DI repression of peroxisome proliferators-activated receptor gamma expression and trans-activationJ.Mol Cell Biol,2003,23(17):6159-6173.22Houseknecht KL,Coleb M,Steele PJ.Peroxisome proliferator-activated receptor gamma(PPAR gamma)and its ligands:a reviewJ....
十四年前,核因子活化B细胞κ轻链增强子(NF-κB)首次被证明是将持续性感染、慢性炎症与肿瘤风险增加联系在一起的关键因子。目前,炎症和肿瘤这一新兴领域研究已日趋成熟,炎症也已被广泛认可为肿瘤的标志和原因之一。2018年《Nature Review. Immunology》杂志上发表了题为《NF-...
〔Abstract〕Nuclear factor –kappaB is a dimer transcription factor from Rel family and a major regulatory factor of the immunity, inflammation and stress reaction.It is involved in the main patho-and physio- procedure of rheumatoid arthritis.Herein,we review research on the relationship of nuclear...
diabetes.Throughareviewandevaluationofexisting literature,thisarticlesummarizestheassessmentmethods, influencingfactors,andinterventionstrategiesofdiabetic pain.Atthesametime,thisarticlealsointroducesthe researchmethodsandresults,andpointsoutthelimitations ofresearchandfutureresearchdirections. ...
[22]Houseknecht KL,Coleb M,Steele PJ.Peroxisome proliferator-activated receptor gamma(PPAR gamma)and its ligands:a review[J].Domest Anim Endocrinol,2002,22(1):1-23. [23]Kotantinopoulos PA,Vandoros GP,Sotiropoulou-Bonikou G,et al.NF-kappa B/PPAR gamma and/or AP-1/PPAR gamma‘ooff’...
[4] Maeder M,Klein M.Contrast nephropathy:Review focusing on prevention.J Am Coll Cardiol 2004;44(9):1763-1771[10.1016/j.jacc.2004.06.075]. [5] Goldenberg I,Matetzky S.Nephropathy induced by contrast media:Pathogenesis,risk factors and preventive strategies.CMAJ 2005;172(11):1461-1471[10.15...
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