UBASH3A Mediates Risk for Type 1 Diabetes Through Inhibition of T-Cell Receptor-Induced NF-kappa B Signaling 喜欢 0 阅读量: 29 作者:Concannon,Patrick,McIntyre,Lauren,M.,Ge,Yan,Paisie,Taylor,K.摘要: Although over 40 type 1 diabetes (T1D) risk loci h ...
Successful spermatogenesis requires autocrine, paracrine, and endocrine signaling throughout the testes. The seminiferous tubules contain somatic Sertoli cells in tight association with numerous germ cell populations. To address the in vivo biologic roles of genes during spermatogenesis, spatial and temporal...
In ABC-DLBCL, activation and maintenance of NF魏B is mediated by the B-cell receptor (BCR) signaling pathway, the ubiquitin-proteasome system (UPS), oncogenic CARD11 or MYD88 mutations, and/or the effect of IRF4/SPIB on CARD11 or MYD88. Optimal NF魏B targeting is an attractive ...
(Cell Signaling Technology (CST), Cat# 9806, USA); BSA (Sigma-Aldrich, Cat# A3059, Burlington, MA, USA); Triton X-100 (Sigma-Aldrich, Cat# T9284, Burlington, MA, USA); Rhodamine 123 (Thermo Fisher Scientific, Cat# R302, Waltham, MA, USA); Phalloidin-FITC (Sigma-Aldrich, Cat# P...