Excessive free radicals activate the NF-kappa B signaling pathway and MAPK signaling pathway, contributing to the activation of AP-1 and NF-kappa B. Then it increased the level of TNF-alpha and the expression of MMPs, which induce the degradation of ECM and accelerated skin aging. We also ...
In different nucleated cells, NF-kappa B has long been considered a prototypical proinflammatory signaling pathway with the expression of proinflammatory genes. Although platelets lack a nucleus, a number of functional transcription factors are involved in activated platelets, such as NF-kappa B. In ...
nf—κb信号通路在脑缺血再灌注损伤中的作用及中药有效组(成)分的干预研究:the role of nf - kappa b signaling pathway in cerebral ischem 星级: 5页 Role of nuclear factor kappa B (NF-κB) in oxidative stress-induced defective dopamine D1 receptor signaling in the renal proxim 星级: 9页 Inv...
• NF-κB signaling is involved in ammonia-induced bioenergetics regulation. Abstract Hyperammonemia is very toxic to the brain, leading to inflammation, disruption of brain cellular energy metabolism and cognitive function. However, the underlying mechanism(s) for these impairments is still not fully...
NF-kappa B signaling pathway inhibition suppresses hippocampal neuronal apoptosis and cognitive impairment via RCAN1 in neonatal rats with hypoxic-ischemic brain... Fang, HuaLi, Hua-FengYang, MiaoLiao, RenWang, Ru-RongWang, Quan-YunZheng, Peng-ChengZhang, Fang-XiangZhang, Jian-Ping - 《Cell Cyc...
We found that basal synaptic input activates the NF-kappa B transcription factor by a pathway requiring the Ca(2+)/calmodulin-dependent kinase CaMKII and local submembranous Ca(2+) elevation. The p65:p50 NF-kappa B form is selectively localized at synapses; p65-deficient mice have no ...
This study demonstrates the efficacy of Delta C-IKK gamma as a repressor of IKK signaling and NF-kappa B activation and suggests a potential gene therapy approach to limit chronic inflammation due to chemokine hyperactivation. 展开 关键词: AIDS/HIV NL4-3 IIIB T lymphocyte signal transduction JAK...
signaling pathway.Blockage of TNF-α-induced NF-κB activation by transient transfection with a mutant IκB enhanced the sensitivity of cells towards TNF-α-induced apoptosis.Conclusion In human gastric cancer cells,activation of NF-κB signaling pathway by TNF-α might be responsible for the ...
KRAS / NF~κB / YY1 / miR~ 489 signaling axis controls pancreatic cancer metastasis[ J] .Cancer Resꎬ2017ꎬ77:100~ 111.Yuan, P.; He, X.H.; Rong, Y.F.; Cao, J.; Li, Y.; Hu, Y.P.; Liu, Y.; Li, D.; Lou... P Yuan,Xiao-Hong He,Ye-Fei Rong,... - 《Cancer ...
B-cell lymphoma 10 (Bcl10) is a scaffolding protein that functions as an upstream regulator of NF-kappa B signaling by forming a complex with Mucosa-associ... D Yang,G Pei,Dong, ShuangshuangZhang, WenhaoDeng, HaitengZhao, XueqiangLi, PilongLin, Xin - science china-life sciences 被引量...