2043#Background:Patients with glioblastoma (GBM) face three major challenges. First, the tumor itself as well as chemoradiation treatment result in lymphopenia, which is associated with shorter survival. Second, the tumor microenvironment (TME) has a paucity of T cells and consequently, ...
被引量: 0发表: 2023年 Targeting Tumor-Associated Macrophages with Antibody-Directed Enzyme Prodrug Therapy in Glioblastoma Cancer is one of the leading causes of mortality. While cancer treatments have advanced substantially, issues, such as side effects and the ability to deliver enough chemotherapy ...
The brain cancer glioblastoma (GBM) is characterized by the presence of cells that can mimic human neurons, even growing axons and making active connections with healthy brain neurons. This cancer almost always recurs after initial treatment, and recurrent tumors are always resistant to therapy. ...
We also discuss the possibility of targeting p53-mediated ferroptotic responses for the treatment of human cancers and potentially, other diseases.This is a preview of subscription content, access via your institution Access optionsSubscribe to this journal Receive 12 print issues and online access ...
Glioblastoma multiforme (GBM) is an extremely aggressive malignant brain tumor. Despite advances in treatment modalities, it remains largely incurable. This unfavorable prognosis for GBM is at least partly due to the lack of a successful drug delivery system across the blood-brain barrier (BBB). Th...
Exosomes in sarcoma: Prospects for clinical applications 2023, Critical Reviews in Oncology/Hematology Citation Excerpt : There was a significant sorting of exosomal proteins, such as KIT and SPRY4, after chemotherapy of metastatic patients as compared with the pre-treatment levels (Atay et al., 20...
Abstract 533: Astrocytes enhance the migration potential of glioblastoma stem-like cells Glioblastoma (GBM) cells in situ are characterized as highly invasive and migratory: properties considered a barrier to successful treatment. The mechanism... BH Rath,K Camphausen,PJ Tofilon - 《Cancer Research》...
having seizures. The spots were in an especially sensitive area on the left side of her brain, so her doctors were reluctant to do a biopsy. It was ultimately necessary, though, and it confirmed that Nicole had glioblastoma – a complex, deadly, fast-moving, treatment-resistant brain cancer...
Future perspectives: bacteriobots technique for cancer therapy In certain publications, "bacteriobot" refers to a novel and inventive theranostic approach utilizing bacteria-based construction for tumor treatment [300,301]. But, in a broader sense, it may be used for any bacteria that has undergone...
we are moving forward with the submission of a new drug application for vorasidenib in IDH-mutant diffuse glioma to the U.S. Food and Drug Administration by the end of 2023. We are honored and excited at the prospect...