Glioblastoma (GBM) is one of the most aggressive cancers of the brain. Despite extensive research over the last several decades, the survival rates for GBM have not improved and prognosis remains poor. To date, only a few therapies are approved for the treatment of GBM with the main reasons...
Temozolomide has been widely used as a first-line treatment for GBM. However, poor brain targeting, side effects, and drug resistance limit its application (Wang et al., 2021a). Different approaches have shown that chemotherapeutic agents for the treatment of brain tumors, such as perillyl...
(2008). Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diag‐ nosed glioblastoma multiforme: north central cancer treatment group study N0177. J Clin Oncol, 26, 5603-5609. [7] Cloughesy, T. & Mischel, P. (2011). New strategies in the ...
The researchers demonstrated that inhibition of BACE1 with MK-8931 promoted macrophage phagocytosis of tumor cells and suppressed growth of malignant tumors including glioblastoma. Moreover, radiation enhanced macrophage infiltration into glioblastoma and synergized with MK-8931 treatment. To date, the transm...
1. Alpha Tau receives FDA's breakthrough device designation for the treatment of recurrent GBM. New release. Alpha Tau Medical. Ocotber 8, 2021. Accessed October 8, 2021. https://prn.to/3DovKG9 2. Alpha Tau receives breakthrough device designation from the FDA for Alpha DaR...
To date, the standard treatment involving the surgical resection of the tumor mass followed by radio and chemotherapy is associated with overall survival of approximately 1 year. Unfortunately, even after developing new alternative therapeutic strategies, including immunological approaches, kinase inhibitors,...
treatment. Moreover, a recent study developed a new version of G47∆ expressing IL-2 (G47Δ-mIL2), which can significantly prolong the survival of different GBM mouse models associated with increased intratumoral CD8+T cells, suggesting that G47Δ-mIL2 may represent a new direction of HSV...
For this reason, new searches for GBM treatment are being sought. Modified ketogenic diet (MKD) (low glycemic index diet) is one of these novel approaches. The primary purpose of this diet is to increase fat consumption and reduce carbohydrate intake. In this wa...
In vivo treatment with diABZI-loaded B-LNPs induced a transcriptomic and metabolic switch in TAMCs, turning these immunosuppressive cells into antitumor effectors, which induced T cell infiltration and activation in brain tumors. In preclinical murine models, B-LNP/diABZI administration synergized with ...
GBM comprises 50% of all malignant brain tumors with over 14,000 new cases expected in 2023 in the US1. Current treatment includes surgical resection followed by radiotherapy and concomitant chemotherapy using temozolomide (TMZ)2. Since 2005 the only new therapies that have been FDA approved for...