Generally, Surgery, radiotherapy, and chemotherapy as existing treatments for GBM ultimately increase the patient’s survival by only a few months [7]. New approaches in glioblastoma control The limitations of the effectiveness of existing therapies for GBM and the existence of mechanisms that ...
This chapter provides a timely overview of new drugs under development for glioblastoma therapy. First, we describe the challenges to drug development that are specific to glioblastoma and inherent issues that explain the high failure rate of late phase clinical trials against these tumors. We ...
Indeed, inhibition of Pcyt1a exhibited anti-lymphoma activity on glioblastoma and DLBCL in vitro and in vivo [34]. As in DLBCL lymphomas, we found in our mAITL mouse model that the neoplastic lymphoma T cells showed a significant upregulation of Pcyt1a, which might represent in addition to...
further research is warranted to overcome the translational glitches that prevent their clinical use. Non-invasive approaches like intranasal administration, P-glycoprotein (P-gp) inhibition, pro-drugs, and
Advanced-disease treatments Recent chemotherapy trials in the advanced/recurrent disease setting have not shown significant outcome improvements over prior single-agent chemotherapy studies. For example, a phase 3 randomized trial of second-line ixabepilone, an anti-tubulin epothilone, versus paclitaxel or...
Pyroptosis, an inflammatory form of PCD, has emerged as a promising avenue for antitumor treatments. Pyroptosis was first described in 1986. Friedlander et al. treated primary mouse macrophages with the anthrax toxin and found that the macrophages rapidly underwent cytolytic death with a non-specific...
With advances in modern biotechnology, well-designed novel antibodies are finally paving the way for successful treatments of various cancers, including precise tumor immunotherapy, in the clinic. Similar content being viewed by others Antibody-based cancer therapy ...
Additionally, most chemotherapeutic agents are associated with systemic side effects and toxicity in both tumour and healthy cells, highlighting the need for alternative treatments. Glioblastoma (GBM), recognised as the most common primary brain tumour and lethal form of brain cancer, accounts for more...
Significant advancements have been made in the application of chimeric antigen receptor (CAR)-T treatment for blood cancers during the previous ten years. However, its effectiveness in treating solid tumors is still lacking, necessitating the exploration
2022a). These findings show the significance of miRNA-based treatments for CNS illnesses associated with NLRP3 inflammasome. Long non-coding RNAs: lncRNAs, which are around 200 nucleotides lengthy play a variety of roles in biological functions, including regulating DNA synthesis, transcription, and ...