GlioblastomaIntroduction Glioblastoma (GBM) is a complex disease with high intratumoral heterogeneity, understanding the molecular characteristics of intratumoral heterogeneity accurately is the basis for precision treatment. Although the existing typing strategy based on tumor molecular characteristics has a ...
New therapeutic strategies regarding endovascular treatment of glioblastoma, the role of the blood–brain barrier and new ways to bypass it The treatment protocols for glioblastoma multiforme (GBM) involve a combination of surgery, radiotherapy and adjuvant chemotherapy.Despite this multimodal ... S,Pes...
The brain cancer glioblastoma (GBM) is characterized by the presence of cells that can mimic human neurons, even growing axons and making active connections with healthy brain neurons. This cancer almost always recurs after initial treatment, and recurrent tumors are always resistant to therapy. ...
We also discuss the possibility of targeting p53-mediated ferroptotic responses for the treatment of human cancers and potentially, other diseases.This is a preview of subscription content, access via your institution Access optionsSubscribe to this journal Receive 12 print issues and online access ...
LyP-1 receptor expression has been shown to be present in many cancers, including breast, prostate, melanoma, glioblastomas, and pancreas, etc. Therefore, mHAdLyp.sT -induced cell death would release tumor-related antigens, such as tumor-associated antigens (TAAs), pathogen- or damage-...
Glioblastoma multiforme (GBM) is an extremely aggressive malignant brain tumor. Despite advances in treatment modalities, it remains largely incurable. This unfavorable prognosis for GBM is at least partly due to the lack of a successful drug delivery system across the blood-brain barrier (BBB). Th...
A team led by Texas A&M University's College of Veterinary Medicine & Biomedical Sciences' (CVM) researcher Dr. Stephen Safe has discovered a new pathway that may help suppress the development of glioblastoma tumors, one of the deadliest forms of can
The Wanted singer passed away on March 30 from a terminal stage 4 glioblastoma brain tumor. He leaves behind his wife Kelsey Hardwick and two children: Aurelia, 2, and Bodhi, 1. He was able to perform at the band’s final reunion show in March before his death. Estelle Harris Frederick...
Brit Turner, drummer for country-rock outfitBlackberry Smoke, died on March 3, according to a social media post from the band. He was 57 years old. In fall of 2022, Turner was diagnosed with glioblastoma, which is a fast-growing form of brain cancer, according to theMayo Clinic. He un...
Poor treatment outcomes have been partially attributed to the intratumor heterogeneity and evolution, which helps the tumor resist treatments. However, defining these diverse characteristics throughout the entire glioblastoma tumor, as well as all other types of solid tumors, has remained a challenge as...