the gut is likely to represent at least as important a site of metformin action as the liver in the management of type 2 diabetes.KEYWORDS: Metformin, hepatic glucose production, glucose absorption, incretin hormones, bile salt, gut microbiotaAdditional informationFundingThis paper was no...
A phase I study of temsirolimus and metformin in advanced solid tumours. Invest New Drugs. 2010;Epub ahead of print. Download references Conflict of interest All authors state that they have no conflicts of interest. Author information Authors and Affiliations Department of Medicine, University of ...
Given that (i) the polyol pathway is highly relevant in diabetes, (ii) metformin has been associated with reduced cancer risk and progression, and (iii) cancer genome sequencing has uncovered mutations in genes involved in glucose uptake, investigating the regulation of the AKR1B1-mediated polyol...
“This study strengthens the evidence supporting metformin's potential as a protective agent against non-melanoma skin cancer,” concluded the research team led by senior researcherDr. Tiffany Libby, an assistant professor of dermatology with Brown University. Metformin is now the most w...
Interestingly, in medulloblastoma, METTL3 acts directly on PTCH1 and GLI2, important factors in the Hedgehog pathway, to promote tumor progression [95]. The above results suggest that METTL3 also affects tumor metastasis by regulating important metastasis-related signaling pathways. ...
However, evidence so far suggests metformin could be a useful adjuvant agent, particularly in patients on ADT. Author and article information Contributors Jessica Whitburn: jesswhitburn@gmail.com , jessica.whitburn@balliol.ox.ac.uk Journal Journal ID (nlm-ta): Curr Urol Rep Journal ID (...
D. Metformin and reduced risk of cancer in diabetic patients. BMJ 330, 1304–1305 (2005). Article PubMed PubMed Central Google Scholar Svensson, R. U. et al. Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical ...
Effects of Metformin Combined with Dapagliflozin on Homocysteine, Cystatin C and Beta-2 Microglobulin Levels in Patients with Diabetes Mellitus Author(s):Hui Zhou, Jinya Ding, O. H. Mohammad, L. Wu and S. Yang* DOI:10.36468/pharmaceutical-sciences.spl.468 ...
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Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure. Am. J. Physiol. Heart Circ. Physiol. 301, H459–H468 (2011). Article CAS PubMed Google Scholar Valls-Lacalle, L. et al. Succinate dehydrogenase inhibition with malonate during reperfusion reduces ...