Objective: This review article aimed to assess the role of metformin as an adjuvant therapy to methotrexate in the treatment of generalized psoriasis. Methods: The databases were searched for articles published in English in 3 data bases [PubMed - Google scholar - Science dir...
The available drug weaponry for metabolic syndrome includes aspirin, metformin, peroxisome proliferator-activated receptor agonists, statins, ACE (angiotensin I-converting enzyme) inhibitors and sartans, which are potentially or clinically useful also to the non-alcoholic fatty liver disease patient. ...
Article CAS Google Scholar Gao F, Wen H, Feng S, Li M, Zhu L, Zhang Y, Xi Y, Xiang X (2023) The elevated toxicity of the biodegradation product (guanylurea) from metformin and the antagonistic pattern recognition of combined toxicity: insight from the pharmaceutical risk assessment and ...
Revisit of metformin treatment in polycystic ovarian syndrome Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women; its traditional pharmacological therapy mainly addresses short-term symptom control a... PM Lam,LP Cheung,C Haines - 《Gynecological Endocrinology the Official Journal of ...
(OS). Further assessment of immune cells infiltration has shown that over-expression of CENPF is associated with different pattern of infiltration of immune cells and high TMB/MSI score. Based on the results of gene-drug interaction assessments inhibitors of this protein, such as Cisplatin, ...
The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers. The expression of CDKs is controlled by a complex regulatory network c
Metformin was originally discovered as a drug that inhibits liver glucose production, but is currently used more as a first-line anti-diabetic drug, but its treatment mechanism is not completely clear. A study on the hypoglycemic mechanism of metformin revealed that treatment with metformin can sign...
GLP-1 receptor agonists are recommended as add-on therapy for patients who do not achieve the required limit of HbA1C after 3 months of metformin therapy [77]. GLP-1 receptor agonists are recommended as first-line therapy as an alternative to metformin in patients who cannot tolerate or are...
Drug repositioning or repurposing has gained worldwide attention as a plausible way to search for novel molecules for the treatment of particular diseases
Introduction Metformin is a first-line antihyperglycaemic agent for type 2 diabetes (T2DM). In addition to glycaemic control, it offers benefits related to cardiovascular health, weight neutrality and metabolic syndrome. However, its benefits in kidney transplant recipients remain unclear as metformin ...