Metformin helps some cancer patients.(IN THE NEWS)(Brief article)Richmond, M
Accordingly, the scientists found that metformin causes the generation of reactive oxygen species in the mitochondria of CD8TIL (mtROS) and increases glycolysis. Further, they found that mtROS activated growth pathways in CD8TIL, thus allowing proliferation of these immune cells. Notably, this is a...
The authors reflect on the recommendations presented by the electronic Medicines Compendium (eMC) in Great Britain on the use of the drug metformin among diabetic patients suffering from renal diseases. Topics discussed include a description of the drug, the impact of the eMC recommendation, and ...
Metformin is known to reduce the risk for T2D in obese adults, but its safety and efficacy in children has been largely unknown. Therefore, Dr. Kendall and coauthors sought to determine whether the medication can benefit obese children by looking at the drug's ability to reduce BMI-SDS. Th...
director of male reproductive medicine and surgery, Department of Urology, Stanford University School of Medicine, Stanford, California, who is a co-author of the study, toldMedscape Medical News. "However, if it is confirmed in other populations, then it may begin to enter counseling discussions...
insulin and orally-administered metformin—increases the amount of metformin at the wound site. As metformin can accelerate wound healing, this could be welcome news for the 18.6 million people worldwide (1.6 million in the U.S.) who develop a diabetic foot ulcer, or DFU, in their lifetimes...
“Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered. In particular, the detailed molecular interplays between the AMPK and the mTORC1 pathway in the hepatic benefits of metformin are still ill-defined. Metfo...
A study was done involving assessments of effects of lifestyle interventions, Metformin, or a placebo on cardiovascular outcomes in diabetics.
Background: New therapeutic approaches are needed to improve glycemic control in patients with type 2 diabetes (T2D), a progressive disorder that often requires combination therapy. The present study assessed the efficacy and safety of sitagliptin as add-on therapy to metformin and rosiglitazone in ...
Metformin cuts pancreatic cancer risk.(IN THE NEWS)(Report)(Brief article)Finkel, Jon