KEGG showed that these genes were involved primarily in cytokine receptor interactions, lipid and AS, and neutrophil extracellular trap formation. To determine the interactions among these 57 genes, we constructed a PPI network using STRING according to the library and visualized it with Cytoscape ...
S3A-D). Additionally, GSEA-KEGG results indicated occurrence of neutrophil death in PAH patients (Additional file 4: Fig. S3E). These findings collectively suggested that NETs formation might occur in neutrophils. A total of 540 entries were obtained from GO and KEGG enrichment analysis based on...
2A) and identified the top 30 KEGG pathways (Fig. 2B), and 30 different GO terms engaged in biological process (BP), cellular component (CC), and molecular function (MF) (Fig. 2C). According to functional enrichment analysis, the most associated signaling pathway for NETs is referred to ...
These proteins were enriched in 189 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The downregulated proteins are mainly involved in focal adhesion (n = 5), and the PI3K-Akt signaling pathway (n = 4). The upregulated proteins were related to neutrophil extracellular trap (NET) ...
KEGG enrichment analysis predicted that RDN is associated with MAPK pathway and thus influence the formation of NETs. The MAPK pathway includes p38, ERK1/2 and JNK, all of which have essential functions in lung injury (Chen et al., 2015). Previous studies demonstrated ROS-inducing receptors an...
Cerebral Cavernous Malformation (CCM) is a brain vascular disease with various neurological symptoms. In this study, we describe the inflammatory profile in CCM and show for the first time the formation of neutrophil extracellular traps (NETs) in rodents and humans with CCM. Through RNA-seq analys...
2A) and identified the top 30 KEGG pathways (Fig. 2B), and 30 different GO terms engaged in biological process (BP), cellular component (CC), and molecular function (MF) (Fig. 2C). According to functional enrichment analysis, the most associated signaling pathway for NETs is referred to ...
To delve deeper into the molecular mechanisms of two NETs-related hub genes in the context of NAFLD diagnosis, ssGSEA-KEGG pathway enrichment analysis was applied to each gene biomarker. The graphical representations highlighted the top six most enriched pathways (as seen in Fig.7A,B and Suppleme...
Abnormalities in ether lipid metabolism as well as the formation of neutrophil extracellular traps have recently been recognized as detrimental factors affecting tumorigenesis and progression. However, the role of abnormal ether lipid metabolism in color
In addition, KEGG pathway analysis showed that NF-kB pathway participated in RAW264.7 cells after treated with uPB-Exo (Fig. S26A). As shown in Fig. S26B, the expression of p-P65 were activated after TNF-α treatment in RAW264.7 cells, implying the detrimental effect of NF-κB activation...