neutrophil extracellular trap formation通路解释 中性粒细胞外围陷阱形成(neutrophil extracellular trap formation,NETosis)是一种特殊的中性粒细胞死亡方式,用于对抗细菌和其他病原体的感染。 NETosis过程包括以下几个步骤: 1.活化:中性粒细胞受到感染或其他刺激后,会经历一系列内部信号转导事件的激活,包括细胞膜上的...
PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling. Eur. J. Immunol. 46, 223–229 (2016). CAS PubMed Google Scholar Amini, P. et al. NET formation can occur independently of RIPK3 and MLKL signaling. Eur. J. Immunol. 46, 178–184 (...
Neutrophil extracellular trap-associated risk index for predicting outcomes and response to Wnt signaling inhibitors in triple-negative breast cancerTriple-negative breast cancer (TNBC) is a type of breast cancer with poor prognosis, which is prone to distant metastasis and therapy resistance. The ...
[3,4,5].MicroorganismsaswellaschemicalcompoundstriggerNETformation,however,themolecu-larmechanismleadingtoreleaseofNETsisonlypoorlycharacterized.ManyNETinducerstriggerMAPkinasesignaling[6],activateNADPHoxidase(Nox2)andinvolvethesubsequentproductionofROS.Thisleadstogranulerupturemediatedbyaproteincomplexcalled“azuro-...
Release of neutrophil extracellular traps (NETs) as a novel antimicrobial defense strategy has gained increasing attention in the past years. Here, we investigated the influx of neutrophils into the dental plaque and the ability of oral bacteria to trigger intra-biofilm release of NETs and ...
Human neutrophil peptide 1-3, a component of the neutrophil extracellular trap, as a potential biomarker of lupus nephritis ObjectiveHuman neutrophil peptides (HNP) were recently implicated in the neutrophil extracellular trap (NET) complex, the impaired degradation of which has... MHH Cheng - 《...
Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis Neutrophil extracellular traps (NETs) play a key role in the development of acute pancreatitis (AP). In the present study, we studied the role of extracellular cold...
Introduction: High-mobility group box 1 (HMGB1) protein is a critical mediator of neutrophil extracellular trap (NET) formation (NETosis). Myeloperoxidase (MPO)- DNA complexes, a biomarker of NETs, and HMGB1 have been associated with delayed cerebral ischemia (DCI) after aneurysma...
Neutrophil extracellular traps in homeostasis and disease Han Wang Susan J. Kim Allan Tsung Signal Transduction and Targeted Therapy (2024) Neutrophil extracellular trap-associated risk index for predicting outcomes and response to Wnt signaling inhibitors in triple-negative breast cancer Zhidong Huang...
NETs induced proliferation, invasion, migration, and EMT of GC cells depend on TGF-β signaling pathway activation TGF-β signaling pathway is the most important activator for EMT, which has also been reported to correlate with several cancers progression and metastasis22, including GC23,24. In ...