Neutrophil Extracellular Traps: Mecha- nisms of formation and role in health and disease [ J ]. Biochemistry (Mosc), 2014, 79(12) :1286 - 1296.Vorobjeva NV,Pinegin BV,Neutrophil extracellular traps:mechanisms of formation and role in health and disease[J].Biochemistry ( Mosc) ,2014,79: ...
中性粒细胞胞外杀菌网络,通常简称为NETs(Neutrophil Extracellular Traps),是中性粒细胞在面对病原体时释放的一种网状结构。这种结构由DNA、组蛋白和抗菌蛋白组成,可以捕捉和杀灭病原体,从而限制感染的扩散。注:《詹韦免疫生物学》9th中文版将Neutrophil Extracellular Traps翻译为“中性粒细胞胞外杀菌网络”,p639名词解...
tion of extracellular traps. During phagocytosis, internal- ized pathogens are translocated to phagosomes where the antimicrobial factors derived from granules and reac- tive oxygen species (ROS) create a killing environment for pathogens. The second mechanism, degranulation, is ...
Neutrophil extracellular traps in immunity and disease Neutrophils are innate immune phagocytes that have a central role in immune defence. Our understanding of the role of neutrophils in pathogen clearance, immune regulation and disease pathology has advanced dramatically in recent years. W... Papaya...
Micl−/−mice exhibit enhanced and non-resolving joint inflammation compared with WT mice during CAIA25(Extended Data Fig.1a). To understand the underlying mechanism, we first determined the cell type (or types) responsible for this phenotype by analysing the cellular infiltrate in the hind paw...
Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential Gouty arthritis (GA) is an immune-mediated disorder characterized by severe inflammation due to the deposition of monosodium urate (MSU) crystals in the jo... C Li,C Wu,F Li,... - ...
neutrophilextracellulartraps(NETs).NETsarereleasedbyPMNsaftertheactivationofaspe- cializedcelldeathpathwayandconsistofchromatinboundtocytoplasmicproteins[3,4,5]. MicroorganismsaswellaschemicalcompoundstriggerNETformation,however,themolecu- larmechanismleadingtoreleaseofNETsisonlypoorlycharacterized.ManyNETinducers trigger...
neutrophil extracellular trapsendothelial cellsthrombosisBackground Essential hypertension (EH) patients, especially those along with hyperhomocysteinemia (HHcy), suffer from increased thrombotic events, however, the underlying mechanism remains unclear to date. Objective We aimed to measure the plasma NETs ...
半滑舌鳎(Cynoglossus semilaevis)中性粒细胞胞外陷阱(neutrophil extracellular traps):产生特征以及抗菌作用 中性粒细胞胞外陷阱(NETs)是中性粒细胞释放到胞外的网状纤维结构,它作为机体一种细胞免疫防御机制抵抗了微生物的入侵。NETs是以DNA作为基本结构骨架,其上间隙附着大量的蛋白结构。 NETs的产生被称作“NETosis”...
[5,6,7], suggests that CCM pathogenesis may follow the two-hit, biallelic molecular mechanism with somatic and germline mutations. Somatic mutations have been found in a growing number of genes, includingKRIT1(CCM1),OSM(CCM2),PDCD10 (CCM3),MAP3K3andPIK3CA, and studies of these genes ...