NeutrophilsMacrophagesExtracellular traps (ETs) are a specialized form of innate immune defense in which leukocytes release ETs composed of chromatin and active proteins to eliminate pathogenic microorganisms. In addition to the anti-infection effect of ETs, researchers have also discovered their ...
Neutrophilextracellular traps(NETs) are complexes of chromosomal DNA, histones, and granule proteins that are released by neutrophils and ensnare extracellular microbes (Yipp and Kubes, 2013;Figure 7). As originally described, NET deployment is coupled to plasma membrane disruption and therefore culminat...
Y. Neutrophils cast extracellular traps in response to protozoan parasites. Front. Immunol. 3, 382 (2012). PubMed Google Scholar Funchal, G. A. et al. Respiratory syncytial virus fusion protein promotes TLR-4-dependent neutrophil extracellular trap formation by human neutrophils. PLoS ONE 10, ...
The role of extracellular traps released by neutrophils, eosinophils, and macrophages in asthma Wei Gu Chunli Huang Guohua Zhen Respiratory Research (2024) Ganglion cell-derived LysoPS induces retinal neovascularisation by activating the microglial GPR34-PI3K-AKT-NINJ1 axis Lushu Chen HuiYing Zhan...
Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) promote the establishment of a pro-thrombotic state. The role of NETs in cancer bio...
However, the mechanism by which the infiltrating neutrophils damage these vital organs during severe sepsis is obscure. Recently, a new neutrophil effector function, neutrophil extracellular traps (NETs), has been reported [18]. NETs are an important part of innate immune defense and are involved ...
neutrophilextracellulartraps(NETs)Theprocesso NETgeneration,callednetosis,isaspeci ctypeo celldeath,diferent romnecrosisandapoptosis.NETsare ormedbyneutrophilsuponcontactwithvariousbacteriaor ungiaswellaswithactivatedplateletsorunderthein uenceo numerousin am-matorystimuli,andthisprocessisassociatedwithdra-matic...
Kang L, Yu H, Yang X, Zhu Y, Bai X, Wang R, Cao Y, Xu H, Luo H, Lu L, et al. Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke. Nat Commun. 2020;11:2488. Chen R, Zhang X, Gu L, Zhu H, Zhong Y, Ye Y, Xiong...
Neutrophil extracellular traps (NETs), which consist of chromatin DNA filaments coated with granule proteins, are released by neutrophils to trap microorganisms1–3. Recent studies have suggested that the DNA component of NETs (NET-DNA) is associated wit
Different cell types release these traps, which are also highly conserved among organisms8,9. The molecular targets guiding the production of NETs depend on the stimulus presented to neutrophils, which can include bacteria, viruses, fungi, parasites, cytokines, laminin, and PMA1,2,3,4,5,6,7,...