in pain transmission is supported by a wealth of evidence. At present. the therapeutic potential of manipulating tachykinin-mediated effects is being investigated and has been assisted by the discovery of several non-peptide, metabolically stable compounds that are antagonists at neurokinin (NK) recept...
Deal watch: Neurokinin 3 receptor antagonist revival heats up with Astellas acquisitionIn France, mutual banks played a key role during the recent period of consolidation of the banking industry because they acquired many privately listed banks. Our analysis of the acquisition of the private bank ...
(redirected from neurokinin receptor antagonist)Also found in: Thesaurus, Medical, Encyclopedia. antagonist a person who opposes another, often in a hostile manner: The man was his antagonist in a duel.; an enemy, foe; the adversary of the hero or protagonist in a literary work Not to be...
Sanger.Effect of a selective and potent central nervous system penetrant, neurokinin-3 receptor antagonist (SB-222200), on cisplatin-induced emesis in the ferret.Neuroscience Letters. 2005King AG, Sanger GJ (2005) Effect of a selective and potent central nervous system penetrant, neurokinin-3 ...
A Neurokinin-1 Receptor (NK1R) antagonist (NK-1RA) that reduces postoperative adhesions reduces the adhesion related chemokines CXCL1(KC) and CXCL2 (MIP-2)... A Neurokinin-1 Receptor (NK1R) antagonist (NK-1RA) that reduces postoperative adhesions reduces the adhesion related chemokines CXCL1(...
The increases in fecal pellet output caused by restraint-stress were inhibited by a neurokinin (NK) 1 receptor antagonist, RP67580 with an ED 50 (95% confidence limits) value of 0.59 (0.54-0.65) mg/kg i.p. RP68651, the enantiomer of RP67580 devoid of affinity for NK 1 receptors, ...
Cannabinoid receptor agonists and antagonists • Antagonists enhance motor activity in colonic smooth muscle IBS CNS adverse effects an issue for CB1 • Agonists (CB1 and CB2) may reduce pain and motility • Antiinflammatory (CB2) 6.29.7.1 Cilansetron (5HT3 Antagonist) Cilansetron 3 is ...
Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-... Optimization of the previously reported 2-phenyl-4-quinolinecarboxamide NK-3 receptor antagonist 14, with regard to potential metabolic ...
Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist 'CJ-17,493' A novel central nervous system (CNS) selective neurokinin-1 (NK) receptor antagonist, (2,3)-3-[(1)-6-methoxy-1-methyl-1-trifluoromethylisochroman-7-yl]-met... Y Shishido,H Wakabayashi...
admin- istration of different doses of the NK1r antagonist (3–100 μg). Previously, repeated local administration of SP in the rat paw also did not show a dose-dependent effect.37 The authors speculated that this could have been due to receptor desensitization. Moreover, in our study, ...