一种神经激肽1受体拮抗剂类药物的合成方法 A method of synthesis of neurokinin 1 receptor antagonist drugsThe invention relates to a novel synthetic method for a compound represented as 5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl)phenyl]oxethyl-3(S)-4-(fluorophenyl)-4-morpholinyl]methyl]-1,2...
The involvement of tachykinin neuropeptides, such as substance P and the neurokinins, in pain transmission is supported by a wealth of evidence. At present. the therapeutic potential of manipulating tachykinin-mediated effects is being investigated and has been assisted by the discovery of several non...
(redirected from neurokinin receptor antagonist)Also found in: Thesaurus, Medical, Encyclopedia. antagonist a person who opposes another, often in a hostile manner: The man was his antagonist in a duel.; an enemy, foe; the adversary of the hero or protagonist in a literary work Not to be...
McCrea JB, Majumdar AK, Goldberg MR, et al. Effects of the neurokinin1 receptor antagonist aprepitant on the pharmacokinetics of dexamethasone and methylpredniso- lone. Clin Pharmacol Ther 2003 Jul; 74 (1): 17-24McCrea JB,Majumdar AK,Goldberg MR,etc.Effects of the neurokinin1 receptor ...
A Neurokinin-1 Receptor (NK1R) antagonist (NK-1RA) that reduces postoperative adhesions reduces the adhesion related chemokines CXCL1(KC) and CXCL2 (MIP-2)... A Neurokinin-1 Receptor (NK1R) antagonist (NK-1RA) that reduces postoperative adhesions reduces the adhesion related chemokines CXCL1(...
Thus, we explored in the Mongolian gerbil the effect on scratching behaviour, induced by intra-dermal injection of the NK-1 receptor-specific agonist GR73632, of oral administration of the NK-1 receptor antagonist orvepitant. Orvepitant at all doses tested (0.1–10mg/kg p.o.) produced ...
Drugs and their administration L760735 (Tocris Bioscience, Bristol, UK) is a high-affinity Neurokinin 1 receptor (NK1) antagonist (IC50 = 0.19 nM at hNK1 receptors), which was dissolved in saline (0.9%) to the required concentration. Intrawound (i.w.) administration was done using a ...
Neurokinin-1 receptor blocking has been shown to be beneficial against lung injury in polymicrobial sepsis. In this paper, we evaluated the possible mediators and the mechanism involved. Mice were subjected to cecal ligation and puncture (CLP-) induced sepsis or sham surgery. Vehicle or SR140333...
The neurokinin-1 receptor antagonist RP 67580 reduces the sensitization of primary afferents by substance P in the rat The inflammatory mediator substance P (SP) produces a variety of biological effects in several tissues by binding to the tachykinin receptor neurokinin 1 (... M Pawlak,RF Schmidt...
中文名称: Neurokinin-1 Receptor Antagonist 中文同义词: 英文名称: Neurokinin-1 Receptor Antagonist 英文同义词: Neurokinin-1 Receptor Antagonist;Neurokinin-1 CAS号: 337505-63-2 分子式: C21H16ClN5OS 分子量: 421.90264 EINECS号: Mol文件: 337505-63-2.mol 337505-63-2 信息错误报告 提交 按...