The development of non-lethal, small-molecule inhibitors that target specific gut microbial activities enables a powerful but underutilized approach to studying the gut microbiome and a promising therapeutic strategy. In this Review, we will discuss the challenges of studying this microbial community, ...
Other therapeutic approaches target components of the peripheral immune system, such as regulatory T cells and monocytes, which in turn act within the CNS. This Review considers in detail how microglia, monocytes and T cells contribute to the pathogenesis of multiple sclerosis, Alzheimer disease, ...
Current treatments for neuropathic pain have limited efficacy; novel therapeutic approaches that target pain-resolving neuroimmune mechanisms provide exciting new avenues to treat neuropathic pain. 目前治疗神经病理性疼痛的方法有限;针对疼痛缓解神经免疫机制的新治疗方法为治疗神经病理性疼痛提供了令人兴奋的新途径。
et al. Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis. Science 347, 1260–1265 (2015). Article CAS PubMed PubMed Central Google Scholar Hotchkiss, R. S., Monneret, G. & Payen, D. Sepsis-induced immunosuppression: from cellular dysfunctions to ...
The ability of a postbiotic, which can be a heterogeneous mixture of components, to mediate a health effect in the target host might be driven by many different mechanisms. In some cases, these mechanisms could be similar to those known for probiotics3,78. Such mechanisms might act independent...
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In order to promote gut lining integrity and health, our products are designed to help fuel your whole body with potent ingredients to support your microbiome. By activating gut microbiome health we can help target the whole body. Digestive System Support ...
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Current treatments for neuropathic pain have limited efficacy; novel therapeutic approaches that target pain-resolving neuroimmune mechanisms provide exciting new avenues to treat neuropathic pain. 目前治疗神经病理性疼痛的方法有限;针对疼痛缓解神经免疫机制的新治疗方法为治疗神经病理性疼痛提供了令人兴奋的新途径...
The findings provide the rationale for combined therapies that target both oncogenic signalling and the tumour microenvironment to overcome PDAC drug resistance. Inhibitors of the RAS–MAPK 更新日期:2024-11-22 详情 收藏 The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract ...