Researchers have used artificial-intelligence models to create regulatory DNA sequences that drive gene expression in specific cell types. Such synthetic sequences could be used to target gene therapies to particular cell populations. Andreas R. Pfenning ...
A postbiotic does not have to be derived from a probiotic for the inactivated version to be accepted as a postbiotic. The beneficial effects of a postbiotic on health must be confirmed in the target host (species and subpopulation). The host can include humans, companion animals, livestock ...
increase the total solid content for optimal curd tension and to improve gel firmness Goat milk yogurt was prepared with 1.25% WPC and SPI each and tested for the viability of starter and probiotic cultures against plain goat milk yogurt (control) during the storage period of 7 days at 4掳C...
Here we used a synthetic biology approach to develop an engineered probiotic Escherichia coli Nissle 1917 strain that colonizes tumours and continuously converts ammonia, a metabolic waste product that accumulates in tumours, to L-arginine. Colonization of tumours with these bacteria increased intra...
lines of research to develop phage therapies to target multi-resistant strains55. The clinical characteristics ofK. pneumoniaeare associated with specific serotypes. Some clones are called hypervirulent because they provoke infections in healthy individuals including liver abscesses. They are almost ...
Excellent studies on genomics of lactic acid bacteria in relation to their role in functional foods have been done by Klaenhammer et al. (2005). Their findings discovered that many genetic features exert control over the bacterial metabolic and probiotic process. Development of resistance to ill ...
Turmeric is an herbal component with a long history of use in India. The active ingredients in Turmeric include beneficial flavonoids called Curcuminoids, which are plant-based antioxidants.* Nature's Bounty Turmeric 1,000mg contains antioxidants, wh...
muciniphila grown on the synthetic medium is safe in humans. These findings provide support for the use of different preparations of A. muciniphila as therapeutic options to target human obesity and associated disorders. Access options Rent or Buy article Get time limited or full article access ...
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TNF can be inhibited by small molecules that stabilize the TNF trimer in an asymmetric conformation. Here, the authors develop a monoclonal antibody that selectively binds this inactive form of TNF, enabling both target engagement assessment and structural characterization of TNF binding to TNF receptor...