In 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of experts specializing in nutrition, microbial physiology, gastroenterology, paediatrics, food science and microbiology to review the definition and scope of postbiotics. The term ‘postbiotics’ is...
Probiotics and prebiotics are microbiota-management tools for improving host health. They target gastrointestinal effects via the gut, although direct application to other sites such as the oral cavity, vaginal tract and skin is being explored. Here, we describe gut-derived effects in humans. In th...
Potential for the development of prebiotic oligosaccharides from biomass. In: Gillian E, Cote` GL, editors. Oligosaccharides in food and agriculture. Oxford: Oxford University Press; 2003. p. 44–53. Google Scholar Roberfroid M. Prebiotics and probiotics: are they functional foods? Am J Clin ...
N. et al. Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Science 374, 1632–1640 (2021). Article CAS PubMed PubMed Central Google Scholar Nomura, M. et al. Association of short-chain fatty acids in the gut microbiome with clinical response to ...
Next-generation, gut microbiome-based therapeutics require biotic and abiotic characteristics influencing grafting of probiotics, metabolic activity and microbial interactions with the resident bacteria to be addressed; emerging strategies should be paired with improved storage stability, improved viability and ...
New data suggest that plasma soluble urokinase receptor (suPAR) might be a predictive biomarker and potential therapeutic target for acute kidney injury (AKI). However, many questions remain regarding the potential of suPAR to inform clinical decision making, identify patients for enrolment in clinical...
T cells in coeliac disease: a rational target for diagnosis and therapy New findings show that disease-specific T cells that target gluten in patients with coeliac disease persist for decades. The data highlight a central role for a highly select and stable population of T cells in disease per...
Iron is critical for the appearance and maintenance of life on Earth. Almost all organisms compete or cooperate for iron acquisition, demonstrating the importance of this essential element for the biological and physiological processes that are key for t
(the receptor for SARS-CoV-2 entry), β2-adrenoceptor, muscarinic M2 receptor, angiotensin II AT1receptor and the angiotensin 1–7 MAS receptor26. High levels of other autoantibodies have been found in some patients with COVID-19 more generally, including autoantibodies that target the tissue (...
For the purification, the salivabactin crude extract was first subjected to a flash chromatography system (Sepra C18 sorbent, 250 g), and fractionated by elution with methanol:water gradient. Then, the fraction that contains the target compound was further subjected to two rounds of high-...