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A good volume of researches exists on nanopore-based electrochemical detection ranging from nucleic acids, peptides, proteins, and biomolecular complexes to organic polymers and small molecules. Due to the advantage of nanopore confinement, new sensing mechanisms have been reported to shed light on ...
In Nanopore-Based Technology, expert researchers in the forefront of the field explore the cutting-edge of nanopore technology for single molecule sensing, detection, and characterization. Divided into four convenient parts, this volume covers single molecule characterization techniques utilizing biological ...
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Inspired by the biological processes of molecular recognition and transportation across membranes, nanopore techniques have evolved in recent decades as ultrasensitive analytical tools for individual molecules. In particular, nanopore-based single-molecule DNA/RNA sequencing has advanced genomic and transcriptomi...
simplicity, label-free, and solution-based detection, therefore widely used in analytical detection [[33], [34], [35], [36], [37], [38], [39], [40], [41], [42]], DNA sequencing [43,44], biomolecular interaction [45,46], and protein unfolding [[47], [48], [49], [50]]...
We present DEMINERS, a novel DRS toolkit combining an RNA multiplexing workflow, a Random Forest-based barcode classifier, and an optimized convolutional neural network basecaller with species-specific training. DEMINERS enables accurate demultiplexing of up to 24 samples, reducing RNA input and run...
Nanopore-based sensors are advancing the sensitivity and selectivity of single-molecule detection in molecular medicine and biotechnology. Current electrical sensing devices are based on either membrane protein pores supported in planar lipid bilayers or solid-state (SS) pores fabricated in thin metallic ...
S. T. Field-based species identification of closely-related plants using real-time nanopore sequencing. Scientific reports 7(1), 8345 (2017). 45. Laver, T. et al. Assessing the performance of the Oxford Nanopore Technologies MinION. Biomolecular Detection and Quantification 3, 1–8 (2015). ...
10. The method according to claim 9, wherein the transmembrane protein is formed of eight identical subunits as shown in SEQ ID NO: 2 or a variant thereof in which one or more of the eight subunits has at least 50% homology to SEQ ID NO: 2 based on amino acid identity over the ent...