BIOLOGICAL NANOPORES FOR BIOPOLYMER SENSING AND SEQUENCING BASED ON FRAC ACTINOPORINThe invention relates generally to the field of nanopores and the use thereof in various applications, such as analysis of biopolymers and macromolecules, typically by making electrical measurements during translocation ...
VIB and ONT have jointly filed two provisional patent applications on the construction and use of dual-constriction pores in nanopore sensing applications (PCT/GB2018/051858 and PCT/GB2018/051191). VIB has a funded research collaboration agreement with ONT related to CsgG-derived nanopores. ONT us...
Graphene nanopores (GNPs) hold great promise as sensors for biological and chemical sensing applications because of their potential in achieving ultra-high sensitivity and sizeable operating currents. However, it remains a challenging task to realize the full potential of GNP sensors in real biological...
Nanopores are powerful tools for single鈥恗olecule sensing of biomolecules and nanoparticles. The signal coming from the molecule to be analyzed strongly d... M Baldelli,GD Muccio,A Sauciuc,... - 《Advanced Materials》 被引量: 0发表: 2024年 Whole genome characterization of chronological age゛ss...
It is thus possible to use arrays of nanopores in sensing to detect multiple blocking and unblocking events simultaneously, which will facilitate in using nanopore blockade sensors for quantitative analysis. Finally, the analytical performance of the 3 × 3 array was assessed. The ability of ...
Upon encountering target cancer cells, Apt-a and Apt-b could function as snail tentacles for sensing, but then reassemble into a target-binding shape for disassembly of SATP and subsequent fluorescence (Figure 8A). As a so-called DNA “nanodoctor,” SATP has been successfully implemented in ...
“sense” the cellular environment. This binding is specific and highly regulated. The binding of integrin to specific ECM component could trigger the activation of intracellular signaling pathways, release growth factors and cytokines embedded in the ECM, and sensing the mechanic changes in the ...
[0119] In another aspect, the insertion of biological nanopores into solid-state nanopores to form a hybrid pore can be used in either or both pores in the two-pore method. The biological pore can increase the sensitivity of the ionic current measurements, and is useful when only single-...
Single-molecule analysis of unlabeled proteins using YaxAB nanopores To assess the sensing capability of the YaxAB nanopore, we attempted to capture four proteins of different charges and sizes: holo-transferrin (9.2 × 6.4 × 4.9 nm), Bcl-xL (4.6 × 4.6 × 3.5 nm), FKBP12 (4.5 ×...
& Rant, U. Stochastic sensing of proteins with receptor-modified solid-state nanopores. Nat. Nanotechnol. 7, 257–263 (2012). Article CAS Google Scholar Ying, Y.L., Yu, R.J., Hu, Y.X., Gao, R. & Long, Y.T. Single antibody-antigen interactions monitored via transient ionic ...