Nanoparticles for drug delivery to the lungs. Trends Biotechnol. 25, 563-570.J. C. Sung, B. L. Pulliam, and D. A. Edwards, "Nanoparticles for drug delivery to 158 the lungs," Trends in Biotechnology, vol. 25, no. 12, pp. 563-570, 2007....
lipophilic cytotoxic drugs with MAbs followed by local delivery to the lungs include: direct delivery to lungs, prolonged residence time in the target tissue; continuous release of significant potent drug doses at tumor sites and better cytotoxic drug internalization in tumors allowing improved efficacy...
Lipid nanoparticles (LNPs) for the efficient delivery of drugs need to be designed for the particular administration route and type of drug. Here we report the design of LNPs for the efficient delivery of therapeutic RNAs to the lung via nebulization. We
2022, Advanced Drug Delivery Reviews Citation Excerpt : Non-liver delivery of nucleic acid therapeutics is challenging and requires specific designs for efficient targeting to other organs such as lungs is to be achieved. The local administration of nucleic acids by inhalation was exploited to achieve...
Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity Mengrui Liu Shiqi Hu Ke Cheng Nature Nanotechnology(2024) In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors ...
which are also present in cell membranes, so liposomes are considered to have good biocompatibility and biodegradability. Because of these properties, liposomes have been widely studied as carriers for drug delivery to tumor tissues. The pH value is one of the commonly used factors to stimulate lip...
摘要: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent for treating wet AMD. The nanoparticles are characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery....
Mucoadhesive particles (MAP) have been widely explored for pulmonary drug delivery because of their perceived benefits in improving particle residence in the lungs. However, retention of particles adhesively trapped in airway mucus may be limited by physiologic mucus clearance mechanisms. In contrast, pa...
V. Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells. Adv. Drug Deliv. Rev. 54, 135–147 (2002). Article CAS PubMed Google Scholar Wong, J. et al. Suspensions for intravenous (IV) injection: a review of development, preclinical and clinical...
in the lungs effectively eliminated the infections, decreased adverse effects on the intestinal microbiota by protecting the animals from dysbiosis-associated metabolic syndromes and from opportunistic pathogen infections, and reduced the accumulation of known antibiotic-resistance genes in commensal bacteria. ...