Internal N6-methyladenosine (m6A) modification is one of the most common and abundant modifications of RNA. However, the biological roles of viral RNA m6A remain elusive. Here, using human metapneumovirus (HMPV) as a model, we demonstrate that m6A serves as a molecular marker for innate immun...
RNA modificationIn addition to DNA methylation, reversible epigenetic modification occurring in RNA has been discovered recently. The most abundant type of RNA methylation is N6-methyladenosine (m6A) modification, which is dynamically regulated by methylases ("writers"), demethylases ("erasers") and ...
N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), has been shown to play critical roles in various normal bioprocesses such as tissue development, stem cell self-renewal and differentiation, heat shock or DNA damage response, and maternal-to-zygo...
N6-methyladenosine modification of KLF2 may contribute to endothelial-to-mesenchymal transition in pulmonary hypertension Kang Kang, Jingjing Xiang, Xingshi Zhang, Yuting Xie, Mengting Zhou, Le Zeng, Junhao Zhuang, Jiahao Kuang, Yuanyuan Lin, Bozhe Hu, Qianmin Xiong, Qing Yin, ...
The potential involvement of circular RNAs (circRNAs) and N6-methyladenosine (m6A) modification in the progression of Wilms tumor (WT) has not been fully elucidated. This study investigates the regulatory mechanisms and clinical significance of m6A-modif
Here, we show that N6-methyladenosine (m6A) RNA modification on human circRNAs inhibits innate immunity. Foreign circRNAs are potent adjuvants to induce antigen-specific T cell activation, antibody production, and anti-tumor immunity in vivo, and m6A modification abrogates immune gene activation and ...
The role of N6-methyladenosine modification in the tumor microenvironment The tumor microenvironment (TME) plays a critical role in the growth and survival of breast cancer cells, comprising various cellular and molecular components that promote tumor cell proliferation, angiogenesis, migration, drug resis...
N6-methyladenosine Modification in Bacterial mRNA 来自 Semantic Scholar 喜欢 0 阅读量: 76 作者:R Gao,H Shi,Y Zhang,X Shao,D Xin 摘要: Among more than 140 naturally occurring RNA modifications have been identified, N6-methyladenosine (m6A) is the most abundant messenger RNA (mRNA) modification...
To investigate whether the abnormal activation of the A20/NF-κB signaling pathway was regulated by circGARS, we studied how circGARS enhanced transcriptional levels by directly binding to m6A modification proteins, which might participate in the pathogenesis of SLE. We concentrated on the effect of...
As the most prevalent internal modification on eukaryotic mRNAs, N-methyladenosine (mA) exists in many plant species and requires the evolutionarily conserved methyltransferases, demethylases, and mA binding proteins for writing, erasing, and reading mA, respectively. In plants, mA affects many aspects...