在细胞核中 FTO 作用底物为多聚腺苷酸(polyA)RNA 中的 m6A、核小 RNA(small nuclear RNA,snRNA)中的N6,2'-O-二甲基腺苷(N6,2'-O-dimethyladenosine,m6Am)、tRNA 中的 m1A;而在细胞质中则是 polyA RNA 中的 m6A 和m6A...
m6A modificationDNA virusRNA virusViral infectionN6-methyladenosine (m6A) modification is a dynamic, reversible process and is the most prevalent internal modification of RNA. This modification is regulated by three protein groups: methyltransferases ("writers"), demethylases ("erasers"), and m6A-...
N6-甲基腺嘌呤(N6-methyladenosine,m6A)是真核生物信使RNA(Messenger RNA,mRNA)上含量最多的化学修饰之一。目前发现microRNA,circRNA,rRNA, tRNA和snoRNA上都有发生m6A修饰。 m6A修饰主要发生在RRACH序列中的腺嘌呤上,其功能由“编码器(Writer)”、“消码器(Eraser)”和“读码器(Reader)”决定。越来越多的证据表...
N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), has been shown to play critical roles in various normal bioprocesses such as tissue development, stem cell self-renewal and differentiation, heat shock or DNA damage response, and maternal-to-zygo...
The N6‐methyladenosine (m6A) modification is the most common modification of messenger RNAs in eukaryotes and has crucial roles in multiple cancers, including in urological malignancies such as renal cell carcinoma, bladder cancer and prostate cancer. The m6A RNA modification is controlled by three ...
Fibrosis is an abnormal tissue healing process characterized by the excessive accumulation of ECM components, such as COL I and COL III, in response to tissue injury or chronic inflammation. Recent advances in epitranscriptomics have underscored the impo
Min Shen et al. N6-methyladenosine modification regulates ferroptosis through autophagysignaling pathway in hepatic stellate cells. Redox Biol 2021 Sep 26;47:102151. doi: 10.1016/j.redox.2021.102151. 版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片和音视频资料,版权均属于生物谷网站...
Breast cancer is the most common cancer type among women. Despite advanced treatment strategies, some patients still face challenges in disease control, prompting the exploration of new therapeutic approaches. N6-Methyladenosine (m6A) methylation modific
近日,南京医科大学的研究者们在Molecular Therapy: Nucleic Acids杂志上发表了题为“Novel insights into the interaction between N6-methyladenosine modification and circular RNA《N6-甲基腺苷修饰与环状RNA相互作用的新见解》”的综述性文章,本文综述了m6A和环状RNA的特点和生物学功能,重点介绍了m6A修饰与环状RNA相互作...
N6-Methyladenosine (m6A) refers to methylation of the adenosine base at the nitrogen-6 position. The existence of this modification has been known for some time. It is very common in prokaryotic genomes, but has not been found in appreciable amounts in eukaryotic DNA. It is very common howev...