And m6A methylation regulates the various aspects of RNA metabolism, including structure, maturation, stability, splicing, export, translation and decay. Liver is a vital metabolic and digestive organ in the pathophysiological processes. Recent studies suggested that m6A RNA modification highly regulates ...
Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation.]]>N6-Methyladenosine (m6A) RNA modification is present in messenger RNAs (mRNA), ribosomal RNAs (rRNA), and spliceosomal RNAs (snRNA) in humans. Although mRNA m6A modifications have been extensively studied and shown to play ...
N6-methyladenosine (m6A) RNA methylation is the most prevalent internal modification of mammalian messenger RNA. The m6A modification affects multiple aspects of RNA metabolism, including processing, splicing, export, stability, and translation through the reversible regulation of methyltransferases (Writers)...
(WTAP). METTL3 is the catalytic methyltransferase subunit and METTL14 is the target recognition subunit that binds to RNA. The Virilzer/VIRMA protein directs m6A methylation to the 3’ UTRs and stop codons, and WTAP targets the complex to nuclear speckles, which are sites of RNA processing....
N6-Methyladenosine (m6A) refers to methylation of the adenosine base at the nitrogen-6 position. The existence of this modification has been known for some time. It is very common in prokaryotic genomes, but has not been found in appreciable amounts in eukaryotic DNA. It is very common howev...
m6A-modified genes (DMGs) and metabolites derived from theM. incognita-infected soybean roots. We found that there was a highly negative correlation between m6A methylation and the expression levels of some genes involved in the regulation of plant immune responses, including genes encoding ...
EMTBackground: M6A is the most widespread RNA internal modification that contributes to the transcription of RNA-mediated genes. Increasing evidence suggest that mHuang, GuangzhaoWu, Qing-qingZheng, Ze-nanShao, Ting-ruChen, Yue-chuanZeng, Wei-seng...
Results unveiled that the m6A methylation level was significantly up-regulated, suggesting the high m6A enrichment status in gastric cancer. Subsequently, MeRIP-Seq was performed using gastric cancer cells (SGC-7901), and the m6A profile showed the centralized distribution of m6A modification sites in...
For antibody-based applications requiring high specificity to N6-methyladenosine (m6A) Citations (17)|(1)|Write a Review Application:DB,ELISA,IF,IP, MeRIP Areas of Research:RNA Methylation Clonality:Polyclonal Conjugate:Unconjugated Host:Rabbit ...
Zc3h13 regulates nuclear RNA m6A methylation and mouse embryonic stem cell self-renewal. Mol. Cell 69, 1028–1038.e6 (2018). Article CAS PubMed PubMed Central Google Scholar Yue, Y. et al. VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with...