N~6-MethyladenosineHuman cancerPharmacological targetm~6A modification regulatorDrug developmentN6-Methyladenosine(m6 A) modification is the most pervasive modification of human mRNA molecules. It is reversible via regulation of m6 A modification methyltransferase, demethylase and proteins that preferentially re...
Resistance to cisplatin-based chemotherapy limits the clinical benefit to some bladder cancer patients, and understanding the epigenetic regulation mechanism of cisplatin (CDDP) resistance in bladder cancer from the perspective of N6-methyladenosine (m6A) modification may optimize CDDP-based treatments. The...
N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), has been shown to play critical roles in various normal bioprocesses such as tissue development, stem cell self-renewal and differentiation, heat shock or DNA damage response, and maternal-to-zygo...
近日,南京医科大学的研究者们在Molecular Therapy: Nucleic Acids杂志上发表了题为“Novel insights into the interaction between N6-methyladenosine modification and circular RNA《N6-甲基腺苷修饰与环状RNA相互作用的新见解》”的综述性文章,本文综述了m6A和环状RNA的特点和生物学功能,重点介绍了m6A修饰与环状RNA相互作...
N6-Methyladenosine (m6A) methylation modification is widely present in the modifications of eukaryotic mRNA, lncRNA, and miRNA [4]. It influences mRNA processing, maturation, splicing, transport, translation, and degradation [5]. M6A can regulate functional proteins such as metabolic enzymes, transpor...
Internal N6-methyladenosine (m6A) modification is one of the most common and abundant modifications of RNA. However, the biological roles of viral RNA m6A remain elusive. Here, using human metapneumovirus (HMPV) as a model, we demonstrate that m6A serves as a molecular marker for innate immun...
Min Shen et al. N6-methyladenosine modification regulates ferroptosis through autophagysignaling pathway in hepatic stellate cells. Redox Biol 2021 Sep 26;47:102151. doi: 10.1016/j.redox.2021.102151. 版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片和音视频资料,版权均属于生物谷网站...
N6-甲基腺嘌呤(N6-methyladenosine,m6A)是真核生物信使RNA(Messenger RNA,mRNA)上含量最多的化学修饰之一。目前发现microRNA,circRNA,rRNA, tRNA和snoRNA上都有发生m6A修饰。 m6A修饰主要发生在RRACH序列中的腺嘌呤上,其功能由“编码器(Writer)”、“消码器(Eraser)”和“读码器(Reader)”决定。越来越多的证据表...
[20] Kim G.W., Siddiqui A. N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognitions[J]. Proc Natl Acad Sci U S A. 2021.118(10): e2022024118. [21] Kim G.W., Hasan Imam, et al. N6-methyladenosine modification of hepatit...
Fibrosis is an abnormal tissue healing process characterized by the excessive accumulation of ECM components, such as COL I and COL III, in response to tissue injury or chronic inflammation. Recent advances in epitranscriptomics have underscored the impo