Chemical Name: N6,N6-DIMETHYLADENOSINE Synonyms N6-di-Me-Adenosine;6-Dimethyladenosine;N6,N6-DIMETHYLADENOS;N6-Dimethyladenosine;N,N-Dimethyladenosine;6-N-Dimethyladenosine;N6,N6-DIMETHYLADENOSINE;Adenosine, N,N-dimethyl-;RNA-modified?nucleoside?m62A;6-Dimethylaminopurine D-riboside CBNumber: CB1486...
EXAMPLE:8-n-Heptylamino-N<6>, N<6>-dimethyladenosine. USE:Useful as an oral drug, injection, paraenteral drug such as suppository, etc., as an anodyne. PROCESS:For example, an 8-halogeno-N<6>, N<6>-dimethyladenosine (e.g., 8-bromo-N<6>, N<6>-dimethyladenosine, etc.) shown...
N6,2′-O-Dimethyladenosine结构式 常用名 N6,2′-O-Dimethyladenosine 英文名 N6,2′-O-Dimethyladenosine CAS号 57817-83-1 分子量 295.29400 密度 N/A 沸点 N/A 分子式 C12H17N5O4 熔点 N/A MSDS N/A 闪点 N/A N6,2′-O-Dimethyladenosine用途 N6,2′-O-二甲基腺苷是脂肪和肥胖相关基因...
PREPARATION:2',3'-0-isopropylidene-N<6>,N<6>-dimethyladenosine of formula II is made to react with carboxylic acids or carboxylic acid halides of formula III (X is OH or halogen) and, as necessary, removing the isopropylidene group by acid hydrolysis.ARAKAWA SHINTARO...
The thermal denaturation ultraviolet absorption spectra of N6,N6-dimethyladenylyl(3′→5′)-N6,N6-dimethyladenosine (m62Apm62A), which is a common sequence in 16–18-S ribosomal RNA, in aqueous buffer at pH 7 have been measured over the temperature range 3–90°C. These data have been ...
Studies on the function of two adjacent N 6 , N 6 -dimethyladenosines near the 3′-end of 16S ribosomal RNA of Escherichia coli. II. The effect of the absence of the methyl groups on initiation of protein biosynthesis. J Biol Chem. 1979; 254 :9090–9094. [ PubMed ]...
ChemInform Abstract: Studies on Compounds Related to Antitumor Agents. Syntheses of 8‐Substituted N6,N6‐Dimethyladenosine Derivatives.nucleic acidsThe O-isopropylidene-N,N-dialkyladenosines (I) are converted to the compounds (II) and (III) by dealkylation and subsequent oxidation....
M(6)AMIDENTIFICATIONMETHYLATIONBackground: N6, 2'-O-dimethyladenosine (m(6)Am) is an abundant RNA methylation modification on vertebrate mRNAs and is present in the transcription initiation region of mRNAs. It has recently been experimentally shown to be associated with several human disorders, ...
A 1 H-NMR investigation was carried out on the tetranucleotides U-m 6 2 A-U-m 6 2 A and m 6 2 A-m 6 2 A-U-m 6 2 A (m 6 2 = N 6 -dimethyladenosine) as well as on the hybrid trinucleotide dA-r(U-A). An extensive comparison with m 6 2 A-U-m 6 2 A and other...