N6-甲基脱氧腺嘌呤(6mA)是DNA腺嘌呤6号位氮原子上的甲基化修饰,在多种生命体中具有重要的生物学调控功能。最初,6mA被发现主要存在于原核生物基因组中,用于区分自身基因组和外源DNA,保护自身DNA不被限制性内切酶性降解。近年来,6mA逐渐被发现存在于真菌、衣藻、果蝇和哺乳动物等真核生物基因组(gDNA)和线粒体DNA...
N6-methyldeoxyadenosine (6mA) is a recently discovered DNA modification involved in regulating plant adaptation to abiotic stresses. However, the mechanisms and changes of 6mA under cold stress in plants are not yet fully understood. Here, we conducted a genome-wide analysis of...
N6-methyldeoxyadenosine (6mA or m6dA) was shown more than 40 years ago in simple eukaryotes. Recent studies revealed the presence of 6mA in more prevalent eukaryotes, even in vertebrates. However, functional characterizations have been limited. We u
N6-methyldeoxyadenosine (6 mA) modification, which is enriched in mitochondrial DNA (mtDNA), can be mediated by methylase METTL4. Our study suggested that mitochondrial perturbation caused by Hcy in primary neurons and PC12 cells may be attributable to mtDNA 6 mA modification difference. Hcy ...
N6‐methyldeoxyadenosine (6mA) is a chemical alteration of DNA, observed across all realms of life. Although the functions of 6mA are well understood in bacteria and protists, its roles in animal genomes have been controversial. We show that 6mA randomly accumulates in early...