Drohat AC, Maiti A (2014) Mechanisms for enzymatic cleavage of the N- glycosidic bond in DNA. Org Biomol Chem 12: 8367 - 8378Drohat A.C., Maiti A. Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA. Org. Biomol. Chem. 2014; 12 :8367–8378....
coli or yeast DNA. This MPG gene has been mapped to human chromosome 16 by analysis of a panel of DNAs from mouse/human and hamster/human hybrid cell lines. Function: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA ...
Polverelli, M, Berger, M, Mouret, J-F, Odin, F, Cadet, I (1990) Acidic hydrolysis of the N-glycosidic bond of deoxyribonucleic acid by hydrogen fluoride stabilized in pyridine. Nucleosides Nucleotides 9: pp. 451-452Polverelli, M., Berger, M., Mouret, J.-F., Odin, F., and Cadet...
Uracil-DNA glycosylase: Structural, thermodynamic and kinetic aspects of lesion search and recognition of its repair is initiated by uracil-DNA glycosylases (UNG), ubiquitously found enzymes that hydrolyze the N-glycosidic bond of deoxyuridine in DNA. This... DO Zharkov,GV Mechetin,GA Nevinsky -...
The influence of the changes in the aglyconic and sugar moieties has been examined. The rates of hydrolyses increased as the pH of the solution decreased and the base strength of the parent amine increased. The lability of the C1N bond increased in the order xyloside < lyxoside < riboside ...
Thus, the higher activity of 2-deoxyribose in the glycosidic bond formation might be associated with its enhanced resistance towards degradation. Finally, we studied the nucleobase regioselectivity of the glycosylation. The glycosylation process under irradiation conditions selectively afforded N9 isomers, ...
Although OSTs and NGTs differ in the type of donor substrate (lipid-bound sugars for OSTs versus nucleotide-bound sugars for NGTs), they are both inverting GTs, i.e. they catalyze the formation of a glycosidic bond with inversion of configuration of the donor anomeric carbon22,23. They als...
摘要: 1. IntroductionUracil N-Glycosylase hydrolyzes the N-glycosidic bond between the deoxyribose sugar and uracil in DNA that contains deoxyuridine in place of thymidine.1 The enzyme is fully active at 37°C, 42°C, and 50°C.收藏 引用 批量引用 报错 分享 ...
aIts antibacterial mechanism is that it hydrolyses the β-(1,4)-glycosidic bond in the alternating N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) of the peptidoglycan, causing rupture of Gram positive bacteria cell walls under the effect of osmotic pressure,and the occurrence of ...
Data are presented for the ultraviolet absorption spectra, fluorescence excitation and emission spectra, acid dissociation constants, rate of imidazole ring opening, and rate of glycosidic bond cleavage of these and the corresponding ... B Singer,L Sun,H Fraenkel-Conrat - 《Biochemistry》 被引量:...